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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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S1PR1 / EDG1 / S1P1 Antibody (C‑Terminus) IHC‑plus™ LS‑A1012
S1P1 antibody LS-A1012 is an unconjugated rabbit polyclonal antibody to human S1P1 (S1PR1 / EDG1). Validated for IHC. Tested on 20 paraffin-embedded human tissues.
Catalog
Size
Price
LS-A1012-50
50 µg (1 mg/ml)
$425
In Stock for Immediate Shipment

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Product Description

S1P1 antibody LS-A1012 is an unconjugated rabbit polyclonal antibody to human S1P1 (S1PR1 / EDG1). Validated for IHC. Tested on 20 paraffin-embedded human tissues.

Specifications

Target
Human S1PR1 / EDG1 / S1P1
Synonyms
S1PR1, CD363, CD363 antigen, CHEDG1, ECGF1, EDG-1, D1S3362, EDG1, S1P1, S1P receptor Edg-1, S1P receptor 1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Predicted
Monkey, Bovine, Pig (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated. Also available conjugated with AP, APC, Biotin, FITC, HRP, PE.
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • IHC
  • IHC - Paraffin (6 µg/ml)
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
Synthetic 19 amino acid peptide from C-terminus of human S1PR1 / EDG1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Panda (100%); Marmoset, Bovine, Cat, Pig (95%); Mouse, Rat, Shrew, Elephant, Horse (89%); Hamster (84%).
Epitope
C-Terminus
Specificity
Human S1PR1 / EDG1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About S1PR1 / EDG1 / S1P1
G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P) that seems to be coupled to the G(i) subclass of heteromeric G proteins. Signaling leads to the activation of RAC1, SRC, PTK2/FAK1 and MAP kinases. Plays an important role in cell migration, probably via its role in the reorganization of the actin cytoskeleton and the formation of lamellipodia in response to stimuli that increase the activity of the sphingosine kinase SPHK1. P21453 NM_001400 NP_001391.2


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Images

Immunohistochemistry

Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Immunohistochemistry

Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-S1PR1 / EDG1 antibody LS-A1012 IHC of human heart, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Requested From: United States
Date Requested: 10/17/2018

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