RWDD3

RWD domain containing 3

Enhancer of SUMO conjugation. Via its interaction with UBE2I/UBC9, increases SUMO conjugation to proteins by promoting the: binding of E1 and E2 enzymes, thioester linkage between SUMO and UBE2I/UBC9 and transfer of SUMO to specific target proteins which include HIF1A, PIAS, NFKBIA, NR3C1 and TOP1. Isoform 1 and isoform 2 positively regulate the NF-kappa-B signaling pathway by enhancing the sumoylation of NF-kappa-B inhibitor alpha (NFKBIA), promoting its stabilization which consequently leads to an increased inhibition of NF-kappa-B transcriptional activity. Isoform 1 and isoform 2 negatively regulate the hypoxia-inducible factor-1 alpha (HIF1A) signaling pathway by increasing the sumoylation of HIF1A, promoting its stabilization, transcriptional activity and the expression of its target gene VEGFA during hypoxia. Isoform 2 promotes the sumoylation and transcriptional activity of the glucocorticoid receptor NR3C1 and enhances the interaction of SUMO1 and NR3C1 with UBE2I/UBC9. Has no effect on ubiquitination.

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Products

Antibodies (19)

Proteins (6)

Type

Over-Expression Lysate (4)

Primary (19)

Recombinant (2)

Target

RWDD3 (25)

Reactivity

Human (19)

Mouse (5)

Rat (2)

Dog (3)

Application

IHC (9)

IHC-P (2)

WB (18)

Flo (6)

ELISA (9)

Host

rabbit (13)

mouse (6)

Product Group

IHCPlus (2)

Isotype

IgG (9)

IgG1 (2)

IgG2a (4)

Clonality

monoclonal mc (6)

polyclonal pc (13)

Clone

OTI10H4 (2)

OTI2A4 (2)

OTI8B3 (2)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

Carrier-free (3)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (11)

Epitope

aa1-267 (6)

aa174-204 (6)

aa92-141 (4)

Publications

No (25)

Tag

GST (1)

Myc-DDK (Flag) (5)

Species

Human (4)

Source

293T Cells (2)

HEK 293 Cells (3)

Wheat Germ Extract (1)

Purification

Purified (1)

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IHC-plus™ RWDD3 Antibody LS-B5040

(4.0) Rating

Antibody:

RWDD3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

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RWDD3 Antibody (aa174-204) LS-C324869

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa174-204) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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RWDD3 Antibody (aa174-204, Biotin) LS-C240317

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa174-204) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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RWDD3 Antibody (aa174-204, FITC) LS-C240318

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa174-204) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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RWDD3 Antibody (aa174-204, Azide-free, HRP) LS-C248065

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa174-204) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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RWDD3 Antibody (aa174-204, APC) LS-C240316

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa174-204) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

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RWDD3 Antibody (aa174-204, PE) LS-C240321

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa174-204) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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IHC-plus™ RWDD3 Antibody LS-B5041

(4.0) Rating

Antibody:

RWDD3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

0.05 mg/$460

Select

RWDD3 Antibody LS-C754095

Antibody:

RWDD3 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC

Format:

Unconjugated

Price:

100 µg/$351

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RWDD3 Antibody (aa1-267, clone OTI8B3) LS-C796083

Antibody:

RWDD3 Mouse anti-Human Monoclonal (aa1-267) (OTI8B3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

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RWDD3 Antibody (aa1-267, clone OTI8B3, Carrier-free) LS-C792926

Antibody:

RWDD3 Mouse anti-Human Monoclonal (aa1-267) (Carrier-free) (OTI8B3) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

RWDD3 Antibody (aa1-267, clone OTI2A4) LS-C796089

Antibody:

RWDD3 Mouse anti-Human Monoclonal (aa1-267) (OTI2A4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

RWDD3 Antibody (aa1-267, clone OTI2A4, Carrier-free) LS-C792934

Antibody:

RWDD3 Mouse anti-Human Monoclonal (aa1-267) (Carrier-free) (OTI2A4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

RWDD3 Antibody (aa1-267, clone OTI10H4) LS-C796090

Antibody:

RWDD3 Mouse anti-Human Monoclonal (aa1-267) (OTI10H4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$434

Select

RWDD3 Antibody (aa1-267, clone OTI10H4, Carrier-free) LS-C792935

Antibody:

RWDD3 Mouse anti-Human Monoclonal (aa1-267) (Carrier-free) (OTI10H4) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated, Carrier-free

Price:

100 µg/$511

• Unconjugated
• Unconjugated, Carrier-free

• Unconjugated
• Unconjugated, Carrier-free

Select

RWDD3 Antibody (aa92-141) LS-C151358

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa92-141) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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RWDD3 Antibody (aa92-141, HRP) LS-C466191

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa92-141) (HRP) Antibody

Reactivity:

Mouse, Dog, Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

RWDD3 Antibody (aa92-141, Biotin) LS-C465772

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa92-141) (Biotin) Antibody

Reactivity:

Mouse, Dog, Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

RWDD3 Antibody (aa92-141, FITC) LS-C465773

Antibody:

RWDD3 Rabbit anti-Human Polyclonal (aa92-141) (FITC) Antibody

Reactivity:

Mouse, Dog, Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

Human RWDD3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G71584

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.9 kDa

Price:

20 µg/$1,107

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Human RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90134

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.9 kDa

Price:

20 µg/$150

Select

Human RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G90135

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.3 kDa

Price:

20 µg/$150

Select

Human RWDD3 Protein (Recombinant GST) (Full Length) - LS-G33043

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

48.5 kDa

Price:

10 µg/$479; 25 µg/$670

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RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G124743

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

21.9 kDa

Price:

100 µg/$494

Select

RWDD3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G113189

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

30.3 kDa

Price:

100 µg/$494

Viewing 1-25 of 25 product results

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