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| Catalog Number | Size | Price |
|---|---|---|
| LS-C154254-100 | 100 µg (0.82 mg/ml) | $567 |
Polyclonal Rabbit anti‑Human RRM2B / P53R2 Antibody (N‑Terminus, IHC, WB) LS‑C154254
Polyclonal Rabbit anti‑Human RRM2B / P53R2 Antibody (N‑Terminus, IHC, WB) LS‑C154254
Note: This antibody replaces LS-C91195
Antibody:
RRM2B / P53R2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Antibody:
RRM2B / P53R2 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Application:
IHC, WB, ELISA
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
P53R2 antibody LS-C154254 is an unconjugated rabbit polyclonal antibody to human P53R2 (RRM2B) (N-Terminus). Validated for ELISA, IHC and WB. Cited in 3 publications.
Target
Human RRM2B / P53R2
Synonyms
RRM2B | MTDPS8A | MTDPS8B | p53R2 | PEOA5
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Chimpanzee, Orangutan, Pig, Drosophila, Macaque (at least 90% immunogen sequence identity)
Clonality
IgG
Polyclonal
Conjugations
Unconjugated
Modifications
Unmodified
Immunogen
Anti-Human RRM2B/p53R2 antibody was prepared by repeated immunizations with a synthetic peptide corresponding to a region near the N-terminus of human RRM2B1 protein. A residue of cysteine was added to facilitate coupling.
Epitope
N-Terminus
Specificity
Anti-Human RRM2B/p53R2 is directed against RRM2B and reacts with the RRM2B from human tissues. Based on sequence we expect this antibody to react as well with RRM2B from other species. Based on 100% homology to the immunizing sequence, one may expect reactivity to chimpanzee and orangutan; based on 93% homology, reactivity to macaque, and 92% to pig and Drosophila.
Applications
- IHC
- Western blot (1 µg/ml)
- ELISA (1:3000)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
RRM2B/p53R2 antibody is suitable for IP, IHC, IF, ELISA and western blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band approximately 41 kD in size corresponding to RRM2B1 by western blotting in the appropriate cell lysate or extract.
Presentation
0.02 M Potassium Phosphate, pH 7.2, 0.15 M NaCl, 0.01% Sodium Azide
Storage
Short term: store at 4°C. Long term: aliquot and store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About RRM2B / P53R2
LSBio Ratings
RRM2B / P53R2 Antibody (N-Terminus) for IHC, WB/Western, ELISA LS-C154254 has an LSBio Rating of
Publications (4.2)
Learn more about The LSBio Ratings Algorithm
Publications (3)
Ribonucleotide reductase small subunit M2B prognoses better survival in colorectal cancer. Liu X, Lai L, Wang X, Xue L, Leora S, Wu J, Hu S, Zhang K, Kuo ML, Zhou L, Zhang H, Wang Y, Wang Y, Zhou B, Nelson RA, Zheng S, Zhang S, Chu P, Yen Y. Cancer research. 2011 71:3202-13.
Ribonucleotide reductase subunit p53R2 regulates mitochondria homeostasis and function in KB and PC-3 cancer cells. Wang X, Liu X, Xue L, Zhang K, Kuo ML, Hu S, Zhou B, Ann D, Zhang S, Yen Y. Biochemical and biophysical research communications. 2011 410:102-7.
RRM2B suppresses activation of the oxidative stress pathway and is up-regulated by p53 during senescence. Kuo ML, Sy AJ, Xue L, Chi M, Lee MT, Yen T, Chiang MI, Chang L, Chu P, Yen Y. Scientific reports. 2012 2:822.
Customer Reviews (0)
Featured Products
Species:
Human, Monkey, Mouse, Rat, Bat, Bovine, Horse, Pig, Rabbit, Sheep, Chicken, Xenopus
Applications:
Western blot
Species:
Human, Mouse, Rat
Applications:
IHC - Paraffin, Immunofluorescence, Western blot
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species:
Human
Applications:
Flow Cytometry, Functional Assay
Reactivity:
Range:
0.156-100 ng/ml
Reactivity:
Human, Mouse, Rat
Range:
Positive/Negative
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/18/2024
Date Requested: 4/18/2024
