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RP49 / CNG1
cyclic nucleotide gated channel alpha 1
Cnga1 is the alpha 1 subunit of cyclic nucleotide-gated (CNG) cation channels involved in visual and olfactory signal transduction. CNGalpha1-3 are able to form functional homooligomeric channels which control the flow of Na+ and Ca2+ into the outer segment of photoreceptor cells in response to light-induced changes in cGMP concentrations. The retinal rod cGMP-gated cation channel is a hetero-oligomer composed of the alpha subunit Cnga1 and a beta subunit. Cnga1 contains a core region of six putative membrane spanning segments, a cGMP binding domain, a voltage sensor-like motif and a pore region. Calmodulin (CaM) controls the activity of the rod cGMP-gated ion channel by decreasing the apparent cGMP affinity.
| Gene Name: | cyclic nucleotide gated channel alpha 1 |
| Family/Subfamily: | Ion Channel , Cyclic nucleotide gated channel |
| Synonyms: | CNGA1, CNG1, CNCG1, CNG channel alpha-1, CNG-1, Interleukin-1 homologue, RCNC1, Rod alpha CNG channel subunit, RCNCa, RCNCalpha, Rod CNGCalpha, CNCalpha1, CNCG, RETalpha, RP49 |
| Target Sequences: | NM_000087 NP_000078.2 P29973 |
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