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Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3).
Gene Name: | Rabenosyn, RAB effector |
Synonyms: | RBSN, 110 kDa protein, Rabenosyn-5, ZFYVE20 |
Target Sequences: | NM_022340 NP_071735.2 Q9H1K0 |
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