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RBP3 / IRBP

retinol binding protein 3, interstitial

Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively.

Gene Name: retinol binding protein 3, interstitial
Synonyms: RBP3, D10S66, D10S64, IRBP, RBPI, Retinol-binding protein 3, D10S65
Target Sequences: NM_002900 NP_002891.1 P10745

Publications (1)

1
Effects of Ranibizumab and Aflibercept on Human Müller Cells and Photoreceptors under Stress Conditions. Shen W, Yau B, Lee SR, Zhu L, Yam M, Gillies MC. International journal of molecular sciences. 2017 March;18:pii E533. [Full Text Article] [PubMed:28257068] [PMC:PMC5372549]

☰ Filters
Antibodies (63)
Proteins (13)
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RBP3 / IRBP (82)
Human (36)
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rabbit (54)
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monoclonal mc (9)
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RBP3 / IRBP Antibody - Western blot analysis of extracts of various cells.
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
RBP3 / IRBP Protein - Recombinant Retinol Binding Protein 3, Interstitial By SDS-PAGE
Select
E. coli
His, N-Terminal
34.2 kDa
10 µg/$262; 50 µg/$339; 100 µg/$512; 200 µg/$642; 1 mg/$1,623; 500 µg/$1,214; 5 mg/$2,562; 2 mg/$1,796
RBP3 / IRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
RBP3 / IRBP ELISA Kit
Select
Sandwich CLIA
12 x 8-Well Microstrips
Human
31.25 - 2000 pg/ml
Chemiluminescent
Plasma, Serum
1 Plate/$728
RBP3 / IRBP Protein - Purified recombinant protein RBP3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
Select
HEK 293 Cells
Myc-DDK (Flag)
133.4 kDa
20 µg/$1,107
RBP3 / IRBP ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$764
RBP3 / IRBP Antibody - Detection limit for recombinant GST tagged RBP3 is approximately 1 ng/ml as a capture antibody.
Select
RBP3 / IRBP Mouse anti-Human Monoclonal (4F3) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$423
RBP3 / IRBP Antibody
Select
RBP3 / IRBP Rabbit anti-Mouse Polyclonal (aa18-320) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
RBP3 / IRBP Antibody - RBP3 Antibody western blot of mouse lung tissue lysates (35 ug/lane). The RBP3 antibody detected the RBP3 protein (arrow).
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RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
RBP3 / IRBP Antibody - Western blot of recombinant RBP3 / IRBP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa19-320) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
100 µl/$308; 200 µl/$350; 500 µl/$489; 1 ml/$558; 2 ml/$749; 5 ml/$1,217
RBP3 / IRBP Antibody - Western blot of recombinant RBP3 / IRBP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa19-320) (FITC) Antibody
Mouse, Human
WB
FITC Conjugated
100 µl/$334; 200 µl/$387; 500 µl/$565; 1 ml/$682; 2 ml/$919; 5 ml/$1,549
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
RBP3 / IRBP Antibody
Select
RBP3 / IRBP Rabbit anti-Rat Polyclonal (aa1027-1229) (FITC) Antibody
Mouse, Rat
WB
FITC Conjugated
100 µl/$345; 200 µl/$402; 500 µl/$594; 1 ml/$737; 2 ml/$976; 5 ml/$1,676
RBP3 / IRBP Protein - Recombinant Retinol Binding Protein 3, Interstitial By SDS-PAGE
Select
E. coli
His-T7
15.8 kDa
10 µg/$275; 50 µg/$402; 100 µg/$642; 200 µg/$802; 1 mg/$1,876; 500 µg/$1,430; 5 mg/$2,838; 2 mg/$2,060
RBP3 / IRBP Antibody - Immunofluorescent analysis of IRBP staining in MCF7 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 deg C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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RBP3 / IRBP Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
50 µl/$286; 100 µl/$321; 200 µl/$386
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) (FITC) Antibody
Mouse, Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) (PE) Antibody
Mouse, Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal (aa784-811) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
RBP3 / IRBP Antibody - Western blot of recombinant RBP3 / IRBP.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
RBP3 / IRBP Rabbit anti-Mouse Polyclonal (aa1027-1229) Antibody
Mouse
WB
Unconjugated
100 µl/$301; 200 µl/$340; 500 µl/$470; 1 ml/$535; 2 ml/$698; 5 ml/$1,161
RBP3 / IRBP Antibody - Immunohistochemistry of paraffin-embedded Mouse retina using RBP3 Polyclonal Antibody at dilution of 1:50.
Select
RBP3 / IRBP Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC
Unconjugated
20 µl/$250; 60 µl/$286; 120 µl/$349; 200 µl/$439
RBP3 / IRBP Antibody - Western Blot;Sample: Recombinant RBP3, Human.
Select
RBP3 / IRBP Mouse anti-Human Monoclonal Antibody
Human
WB
Unconjugated
100 µl/$305; 200 µl/$346; 500 µl/$481; 1 ml/$549; 2 ml/$729; 5 ml/$1,197
Viewing 1-25 of 82 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).