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RBL2 / RB2 p130

retinoblastoma-like 2 (p130)

Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation, associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.

Gene Name: retinoblastoma-like 2 (p130)
Synonyms: RBL2, p130, Retinoblastoma-like 2 (p130), RBR-2, Rb2, Retinoblastoma-like protein 2
Target Sequences: NM_005611 NP_005602.3 Q08999

☰ Filters
Antibodies (31)
Proteins (6)
ELISA Kits (3)
Custom (1)
Over-Expression Lysate (3)
Primary (31)
Recombinant (3)
Sandwich (2)
RBL2 / RB2 p130 (40)
Human (32)
Mouse (17)
Rat (17)
Bat (6)
Bovine (6)
Chimpanzee (8)
Dog (6)
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rabbit (29)
mouse (2)
Product Group
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monoclonal mc (2)
polyclonal pc (29)
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Azide-free (1)
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aa165-194 (7)
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aa442-491 (4)
890-970 aa (1)
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aa175-189 (1)
aa918-967 (1)
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Purified (1)
RBL2 / RB2 p130 Antibody - Anti-RBL2 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:500.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
50 µl/$515
RBL2 / RB2 p130 Antibody - Anti-RB2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:200.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa175-189) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Rat, Human
ELISA, IHC, IHC-P, IP, WB
Unconjugated
100 µl/$917
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) Antibody
Human
ELISA, Flo, WB
Unconjugated
200 µl/$734
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) (Biotin) Antibody
Human
ELISA, Flo, WB
Biotin Conjugated
200 µl/$952
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) (FITC) Antibody
Human
ELISA, Flo, WB
FITC Conjugated
200 µl/$952
Select
RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, WB
HRP Conjugated, Azide-free
200 µl/$952
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) (APC) Antibody
Human
ELISA, Flo, WB
APC Conjugated
200 µl/$952
Select
RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) (PE) Antibody
Human
ELISA, Flo, WB
PE Conjugated
200 µl/$952
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RBL2 / RB2 p130 Mouse anti-Human Monoclonal (2C8A8) Antibody
Human
ELISA, Flo
Unconjugated
100 µl/$459
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (890-970 aa) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
RBL2 / RB2 p130 Antibody - Peptide - + Immunofluorescence analysis of HeLa cells, using Rb-like-2 antibody.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (Ab-952) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
100 µg/$357
RBL2 / RB2 p130 Antibody - Immunohistochemistry of paraffin-embedded Human ovarian cancer tissue  using RBL2 Polyclonal Antibody at dilution of 1:45(×200)
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
RBL2 / RB2 p130 Antibody - Anti-Spa310 Antibody - Western Blot. Western blot of affinity purified anti-Spa310 antibody shows detection of endogenous pRb2/p130 protein in whole LNCaP cell extracts. The band at ~130 kD, indicated by the arrowhead, corresponds to the expected molecular weight of pRb2/p130. The membrane was blocked overnight with a milk buffer at 4C. Primary antibody was diluted 1:500 and reacted with the membrane overnight at 4C. ECL was used for detection. Personal communication, Ang Sun, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Philadelphia, PA.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Human, Chimpanzee
ELISA, IP, WB
Unconjugated
100 µg/$567
RBL2 / RB2 p130 Antibody - Western blot using the affinity purified anti-Spa310 antibody shows detection of endogenous pRb2/p130 protein in whole LNCaP cell extracts. The band at ~130 kDa, indicated by the arrowhead, corresponds to the expected molecular weight of pRb2/p130. The membrane was blocked overnight with a milk buffer at 4° C. Primary antibody was diluted 1:500 and reacted with the membrane overnight at 4° C. ECL was used for detection.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Human, Chimpanzee
ELISA, IP, WB
Unconjugated
25 µl/$304
RBL2 / RB2 p130 Antibody - Immunofluorescence analysis of HeLa cells, using RBL2 Antibody. The picture on the right is blocked with the synthesized peptide.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa918-967) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
RBL2 / RB2 p130 Antibody - RBL2 Antibody western blot of Jurkat cell line lysates (35 ug/lane). The RBL2 antibody detected the RBL2 protein (arrow).
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa165-194) Antibody
Human
Flo, WB
Unconjugated
400 µl/$393
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$341
RBL2 / RB2 p130 Antibody - Western blot analysis of RBL2 using MCF-7 whole cells lysates
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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RBL2 / RB2 p130 Mouse anti-Human Monoclonal (N-Terminus) (KAB40) Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µg/$466
Select
RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
RBL2 / RB2 p130 Antibody - Western blot of Human HeLa. RBL2 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (aa442-491) Antibody
Human
WB
Unconjugated
100 µl/$424
RBL2 / RB2 p130 Antibody - Western blot of Human Liver Tumor. RBL2 antibody dilution 1.0 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$424
RBL2 / RB2 p130 Antibody - Western blot of RBL2 antibody at 1:500 dilution. Lane 1: HEK293T whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: PC12 whole cell lysate.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
RBL2 / RB2 p130 Antibody - Anti-RB2 Antibody at 1:1000 dilution + Jurkat whole cell lysates Lysates/proteins at 20 ug per lane. Secondary Goat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/10000 dilution Predicted band size : 128 kDa Blocking/Dilution buffer: 5% NFDM/TBST.
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RBL2 / RB2 p130 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
100 µl/$386
Viewing 1-25 of 40 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).