CTIP antibody LS-C501639 is an HRP-conjugated rabbit polyclonal antibody to human CTIP (RBBP8). Validated for ELISA.
Human RBBP8 / CTIP
(tested or 100% immunogen sequence identity)
Also available Unconjugated
or conjugated with FITC
Protein G purified
- (applications tested for the base form of this product only)
RBBP8 / CTIP antibody was raised against recombinant human DNA endonuclease RBBP8 protein (126-331AA)
Endonuclease that cooperates with the MRE11-RAD50-NBN (MRN) complex in processing meiotic and mitotic double-strand breaks (DSBs) by ensuring both resection and intrachromosomal association of the broken ends. Functions downstream of the MRN complex and ATM, promotes ATR activation and its recruitment to DSBs in the S/G2 phase facilitating the generation of ssDNA. Component of the BRCA1-RBBP8 complex that regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage. Promotes microhomology-mediated alternative end joining (A-NHEJ) during class-switch recombination and plays an essential role in chromosomal translocations.
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
For research use only.