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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RB1 / Retinoblastoma / RB Antibody (clone 172C1094) LS‑C510
RB antibody LS-C510 is an unconjugated mouse monoclonal antibody to RB (RB1 / Retinoblastoma) from human and mouse. Validated for IHC and WB.
Catalog
Size
Price
LS-C510-100
100 µg (0.5 mg/ml)
$335
Description
RB antibody LS-C510 is an unconjugated mouse monoclonal antibody to RB (RB1 / Retinoblastoma) from human and mouse. Validated for IHC and WB.
Target
Human RB1 / Retinoblastoma / RB
Host
Mouse
Reactivity
Human, Mouse (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal [172C1094]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • Western blot (2 µg/ml)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Failed Applications
  • IHC - Paraffin
Immunogen
A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
Specificity
recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
Presentation
PBS, 0.02% Sodium Azide
Storage
Short term: 4°C; Long term: -70°C.
Restrictions
For research use only.
About RB1 / Retinoblastoma / RB
P06400 NM_000321 NP_000312.2

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Images

Immunohistochemistry

Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.
Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.

Western blot

Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.
Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.

Immunohistochemistry

Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.
Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.

Western blot

Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.
Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.

Immunohistochemistry

Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.
Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.

Western blot

Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.
Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.

Immunohistochemistry

Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.
Immunohistochemistry of DRb-p70 using antibody in sections of primary human breast tumors.

Western blot

Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.
Western blot analysis: HL60 cells were treated with camptothecin for 24 hours.

Requested From: United States
Date Requested: 12/14/2018
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