RB antibody LS-C510 is an unconjugated mouse monoclonal antibody to RB (RB1 / Retinoblastoma) from human and mouse. Validated for IHC and WB.
Human RB1 / Retinoblastoma / RB
(tested or 100% immunogen sequence identity)
Protein G purified
- Western blot (2 µg/ml)
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A synthetic peptide corresponding to a region of the caspase-3-induced cleavage site of human Rb.
recognizes cleaved Rb (DRb-p70). Does not recognize full-length Rb. In camptothecin treated HL60, an ~68 kD band is observed. DRb-p70 exists in vivo as an N-terminally truncated form of Rb (Liu et al.). DRb-p70 is thought to be the product of alternative translation and is expressed in primary myeloid cells in fetal liver, bone marrow and spleen. DRb-p70 is also specifically expressed in tumor-associated macrophages (TAMs). TAMs are an important targets of cancer therapy. DRb-p70 is a marker of TAMs, and maybe useful for identifying tumors with macrophage infiltration (Liu et al, 2005).
PBS, 0.02% Sodium Azide
Short term: 4°C; Long term: -70°C.
For research use only.
About RB1 / Retinoblastoma / RB