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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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RAPGEF5 / GFR Antibody (aa431‑480) LS‑C120296
GFR antibody LS-C120296 is an unconjugated rabbit polyclonal antibody to GFR (RAPGEF5) from human, mouse and rat. Validated for Peptide-ELISA and WB.
Catalog
Size
Price
LS-C120296-50
50 µl (1 mg/ml)
$265
LS-C120296-100
100 µl (1 mg/ml)
$325

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Product Description

GFR antibody LS-C120296 is an unconjugated rabbit polyclonal antibody to GFR (RAPGEF5) from human, mouse and rat. Validated for Peptide-ELISA and WB.
About RAPGEF5 / GFR
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]). Q92565 D87467 BAA13406.2

RAPGEF5 Antibody, GFR Antibody, KIAA0277 Antibody, M-Ras-regulated Rap GEF Antibody, M-Ras-regulated GEF Antibody, MRGEF Antibody, Related to Epac Antibody, REPAC Antibody, MR-GEF Antibody


Specifications

Target
Human RAPGEF5 / GFR
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (1:500 - 1:1000)
  • Peptide Enzyme-Linked Immunosorbent Assay (1:20000)
Immunogen
RAPGEF5 / GFR antibody was raised against synthetic peptide from human RAPGEF5. (AA Range: 431-480)
Epitope
aa431-480
Specificity
RAPGEF5 Antibody detects endogenous levels of total RAPGEF5 protein.
Usage
Western Blot: Predicted MW 67 kDa
Presentation
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM NaCl, 0.02% Sodium Azide, 50% Glycerol
Storage
Store at -20°C for up to 1 year.
Restrictions
For research use only.

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Images

Western blot

Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot

Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot

Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.

Western blot

Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.
Western blot analysis of lysates from RAW264.7 cells, using RAPGEF5 Antibody. The lane on the right is blocked with the synthesized peptide.

Requested From: United States
Date Requested: 9/23/2018

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