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RAB7A / RAB7 Antibody (Biotin) LS-C499653

Antibody

RAB7A / RAB7 Antibody (Biotin) LS-C499653

Antibody:
Rabbit Polyclonal to Human RAB7A / RAB7
Application:
ELISA
Reactivity:
Human
Format:
Biotin, Unmodified
Other formats:
Price
Catalog Number
$285 
LS-C499653-50
Toll Free North America
866-819-4732

Overview

Antibody:
Rabbit Polyclonal to Human RAB7A / RAB7
Application:
ELISA
Reactivity:
Human
Format:
Biotin, Unmodified
Other formats:

Specifications

Description
RAB7 antibody LS-C499653 is a biotin-conjugated rabbit polyclonal antibody to human RAB7 (RAB7A). Validated for ELISA.

Target
Human RAB7A / RAB7
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Biotin. Also available Unconjugated or conjugated with HRP, FITC.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • ELISA
  • (applications tested for the base form of this product only)
Immunogen
RAB7A / RAB7 antibody was raised against recombinant human Ras-related protein Rab-7a protein (110-177AA)
Specificity
Key regulator in endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA (PubMed:11179213, PubMed:12944476, PubMed:14617358, PubMed:20028791, PubMed:21255211). Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413).
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About RAB7A / RAB7
P51149 NM_004637 AAA86640.1

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Featured Products

Product
Species: Mouse, Human
Applications: Western blot, Immunoprecipitation, Flow Cytometry
Reactivity: Human
Range: 0.156-10 ng/ml
Reactivity: Human
Range: 0.156-10 ng/ml

Requested From: United States
Date Requested: 6/19/2019
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