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PTPRN / IA-2
protein tyrosine phosphatase, receptor type, N
PTPRN / IA-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.
| Gene Name: | protein tyrosine phosphatase, receptor type, N |
| Family/Subfamily: | Protein Phosphatase , R8 |
| Synonyms: | PTPRN, ICA512, IA2, ICA 512, Islet antigen 2, Islet cell antigen 2, Islet cell autoantigen 3, IA-2, Ia-2 antigen, ICA3, PTP-NP-2, PTP IA-2, R-PTP-N, IA-2/PTP, Islet cell antigen 512 |
| Target Sequences: | NM_002846 NP_002837.1 Q16849 |
Publications (1)
1
Presence of diabetes autoantigens in extracellular vesicles derived from human islets. Hasilo CP, Negi S, Allaeys I, Cloutier N, Rutman AK, Gasparrini M, Bonneil É, Thibault P, Boilard É, Paraskevas S. Scientific reports. 2017 7:5000. (ICC, WB, Flo; Human, Hamster)
[Full Text Article]
[PubMed:28694505]
[PMC:PMC5504025]
Related Antibodies: LS-C284886.
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PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa32-81) Antibody
Human
WB
Unconjugated
100 µl/$424
PTPRN / IA-2 Mouse anti-Human Monoclonal (8E3) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$440
Sandwich
96-Well Microplate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
Yeast
6His-Myc, C-terminus
60.3 kDa
100 µg/$446; 20 µg/$336; 1 mg/$1,460
PTPRN / IA-2 Mouse anti-Human Monoclonal Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
100 µg/$371
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$768
Yeast
6His, N-terminus
100 µg/$446; 20 µg/$336; 1 mg/$1,460
E. coli
His
17.8 kDa
10 µg/$283; 50 µg/$452; 100 µg/$722; 200 µg/$902; 1 mg/$2,016; 500 µg/$1,553; 5 mg/$3,151; 2 mg/$2,204
E. coli
6His, N-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
44.6 kDa
10 µg/$344; 50 µg/$584
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa368-575) Antibody
Rat, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
E. coli
His, N-Terminal
Less than 1.0 EU/µg protein (determined by LAL method).
predicted 44.6 kDa, observered 50 kDa
20 µg/$205; 100 µg/$235
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
IHC-P, WB
Unconjugated
100 µl/$412
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PTPRN / IA-2 Rabbit anti-Human Polyclonal (aa288-316) Antibody
Human
WB
Unconjugated
400 µl/$393
PTPRN / IA-2 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
50 µl/$286; 100 µl/$321
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