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PTGER4 / EP4

prostaglandin E receptor 4 (subtype EP4)

PTGER4 / EP4 is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.

Gene Name: prostaglandin E receptor 4 (subtype EP4)
Family/Subfamily: GPCR , Prostanoid
Synonyms: PTGER4, EP4, EP4 prostaglandin receptor, EP4R, PGE receptor EP4 subtype, Prostanoid EP4 receptor, Prostaglandin E receptor 4, PGE receptor, EP4 subtype, PGE2 receptor EP4 subtype
Target Sequences: NM_000958 NP_000949.1 P35408

Publications (3)

1
EP4 and Class III ß-Tubulin Expression in Uterine Smooth Muscle Tumors: Implications for Prognosis and Treatment. Reader J, Harper AK, Legesse T, Staats PN, Goloubeva O, Rao GG, Fulton A, Roque DM. Cancers. 2019 October;11:E1590. [Full Text Article] [PubMed:31635323] [PMC:PMC6826612] Related Antibodies: LS-A3898.
2
Prostaglandin E Receptor EP4 expression, survival and pattern of recurrence in locally advanced NSCLC. Neha Bhooshan, Paul N Staats, Amy M Fulton, Josephine L Feliciano, Martin J Edelman. Lung cancer (Amsterdam, Netherlands). 2016 November;101:88-91. [Full Text Article] [PubMed:27794413] [PMC:PMC7428069] Related Antibodies: LS-A3898.
3
Identification of EP4 as a potential target for the treatment of castration-resistant prostate cancer using a novel xenograft model. Terada N, Shimizu Y, Kamba T, Inoue T, Maeno A, Kobayashi T, Nakamura E, Kamoto T, Kanaji T, Maruyama T, Mikami Y, Toda Y, Matsuoka T, Okuno Y, Tsujimoto G, Narumiya S, Ogawa O. Cancer research. 2010 Feb;70:1606-15. [Full Text Article] [PubMed:20145136] Related Antibodies: LS-A3898.

☰ Filters
Antibodies (27)
Proteins (3)
Primary (27)
Recombinant (3)
PTGER4 / EP4 (30)
Human (27)
Mouse (3)
Rat (2)
Bat (1)
Bovine (2)
Dog (1)
Hamster (1)
Horse (1)
Monkey (6)
Rabbit (1)
Sheep (1)
IHC (6)
IHC-P (7)
WB (19)
ELISA (7)
ICC (5)
IF (4)
Peptide-ELISA (4)
rabbit (26)
goat (1)
Product Group
GPCR Database Antibodies (5)
IHCPlus (6)
PathPlus Cancer (1)
IgG (16)
polyclonal pc (27)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Unconjugated (24)
C-Terminus (4)
2nd Extracellular Domain (1)
300-380 aa, Internal (1)
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Internal (1)
N-Terminus (1)
aa1-23 (1)
aa242-269 (1)
aa302-314 (1)
aa313-362 (1)
aa321-370 (1)
No (29)
Yes (1)
GST (1)
GST, N-terminus (1)
Myc-DDK (Flag) (1)
Human (3)
HEK 293 Cells (1)
Wheat Germ Extract (2)
Purified (1)
PTGER4 / EP4 Antibody - Anti-PTGER4 / EP4 antibody IHC of human colon, ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ICC, IHC-P
Unconjugated
50 µg/$440
PTGER4 / EP4 Antibody - Anti-PTGER4 / EP4 antibody IHC of human colon, ganglion. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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Cancer
Fast Shipping
PTGER4 / EP4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Bovine, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
PTGER4 / EP4 Antibody - Human, Liver: Formalin-Fixed Paraffin-Embedded (FFPE)
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Fast Shipping
PTGER4 / EP4 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Human, Monkey
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
PTGER4 / EP4 Antibody - Human, Pancreas: Formalin-Fixed Paraffin-Embedded (FFPE)
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Fast Shipping
PTGER4 / EP4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Bovine, Rat, Hamster, Horse, Bat, Human, Monkey
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
PTGER4 / EP4 Antibody - Human, Colon: Formalin-Fixed Paraffin-Embedded (FFPE)
Select
Fast Shipping
PTGER4 / EP4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human, Monkey
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
PTGER4 / EP4 Antibody - Anti-PTGER4 / EP4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IHC, IHC-P, WB
Unconjugated
1 Each/$485
PTGER4 / EP4 Antibody - PTGER4 Antibody western blot of HL-60,K562 cell line and mouse brain lysates (35 ug/lane). The PTGER4 antibody detected the PTGER4 protein (arrow).
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (aa242-269) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
PTGER4 / EP4 Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (2nd Extracellular Domain) Antibody
Human
ELISA, WB
Unconjugated
100 µg/$832
PTGER4 / EP4 Antibody - Anti-PTGER4 / EP4 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P, WB
Unconjugated
1 Each/$485
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Rabbit, Human
ELISA, WB
Unconjugated
100 µg/$832
PTGER4 / EP4 Antibody - Western blot analysis of Raji cell, using PTGER4 Polyclonal Antibody at dilution of 1:450.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Mouse, Sheep, Rat, Human
WB
Unconjugated
100 µl/$289
PTGER4 / EP4 Antibody - Staining COLO205 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
PTGER4 / EP4 Antibody - Western blot of EP4 antibody
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (300-380 aa, Internal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
PTGER4 / EP4 Antibody - Immunofluorescence analysis of MCF7 cells, using PE2R4 Antibody. The picture on the right is blocked with the synthesized peptide.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (aa321-370) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PTGER4 / EP4 Antibody - Western blot analysis of LoVo cell, using PTGER4 Polyclonal Antibody at dilution of 1:600.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
PTGER4 / EP4 Antibody - Immunofluorescence staining of HepG2 cells with PTGER4 Antibody at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
PTGER4 / EP4 Antibody - Western blot analysis of the lysates from HeLa cells using PE2R4 antibody.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (aa313-362) Antibody
Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PTGER4 / EP4 Antibody - Antibody (0.1 ug/ml) staining of Human Testes lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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PTGER4 / EP4 Goat anti-Human Polyclonal (aa302-314) Antibody
Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (aa1-23) Antibody
Human
WB
Unconjugated
1 Each/$737
PTGER4 / EP4 Antibody - Western blot - Anti-PTGER4 Picoband Antibody
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
10 µg/$318; 100 µg/$470
PTGER4 / EP4 Antibody - Western blot analysis of EP4 expression in Ramos (A); HeLa (B) whole cell lysates.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal (Internal) Antibody
Human, Monkey
WB
Unconjugated
100 µl/$299
PTGER4 / EP4 Antibody - Western blot testing of human 1) SW620 and 2) MCF7 cell lysate with PTGER4 antibody at 0.5ug/ml. Predicted molecular weight ~53 kDa.
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PTGER4 / EP4 Rabbit anti-Human Polyclonal Antibody
Human
WB
Unconjugated
100 µg/$575
Viewing 1-25 of 30 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).