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PTF1A
pancreas specific transcription factor, 1a
Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates.
| Gene Name: | pancreas specific transcription factor, 1a |
| Family/Subfamily: | Transcription Factor |
| Synonyms: | PTF1A, BHLH transcription factor p48, Class II bHLH protein PTF1A, PTF1-p48, PTF1P48, BHLHa29 |
| Target Sequences: | NM_178161 NP_835455.1 Q7RTS3 |
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