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PRKACB

protein kinase, cAMP-dependent, catalytic, beta

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Gene Name: protein kinase, cAMP-dependent, catalytic, beta
Family/Subfamily: Protein Kinase , cAMP
Synonyms: PRKACB, Cbeta, PKACB, PKA C-beta, PKA Cbeta
Target Sequences: NM_002731 NP_002722.1 P22694

Publications (1)

1
Protein Kinase A in Human Retina: Differential Localization of Cß, Ca, RIIa, and RIIß in Photoreceptors Highlights Non-redundancy of Protein Kinase A Subunits. Jinae N Roa, Yuliang Ma, Zbigniew Mikulski, Qianlan Xu, Ronit Ilouz, Susan S Taylor, Dorota Skowronska-Krawczyk. Frontiers in molecular neuroscience. 2021 December;14:782041. [Full Text Article] [PubMed:34867193] [PMC:PMC8636463] Related Antibodies: LS-C191947.

☰ Filters
Antibodies (37)
ELISA Kits (10)
Proteins (8)
Cell-Based (1)
Custom (6)
Over-Expression Lysate (4)
Primary (37)
Recombinant (4)
Sandwich (3)
PRKACB (55)
Human (41)
Mouse (27)
Rat (16)
Bat (6)
Bovine (7)
Chicken (1)
Chimpanzee (6)
Dog (3)
Gibbon (6)
Guinea pig (6)
Hamster (6)
Horse (6)
Monkey (6)
Orangutan (6)
Pig (8)
Rabbit (6)
IHC (15)
IHC-P (3)
WB (33)
ELISA (21)
IF (6)
IP (1)
Peptide-ELISA (3)
rabbit (36)
mouse (1)
IgG (25)
IgG1,k (1)
monoclonal mc (1)
polyclonal pc (36)
2G8-1D12 (1)
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96-Well Strip Plate (8)
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Azide-free (2)
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FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (18)
aa17-47 (6)
aa292-319 (6)
C-Terminus (5)
N-Terminus (4)
260-340 aa, C-terminal (1)
Asp324 (1)
aa291-340 (1)
pSer338 (1)
No (54)
Yes (1)
Adherent Cell Cultures (1)
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Serum (3)
Tissue Homogenates (3)
GST (1)
GST, N-terminus (1)
His (1)
Myc-DDK (Flag) (5)
Human (6)
293T Cells (2)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (2)
PRKACB Antibody - Immunohistochemistry (IHC) analysis of PKA beta  antibody in paraffin-embedded human brain tissue.
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PRKACB Rabbit anti-Human Polyclonal (Asp324) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$391
PRKACB Antibody - Immunohistochemistry of paraffin-embedded human brain tissue at dilution of 1:100
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PRKACB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
50 µg/$294; 100 µg/$360
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PRKACB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PRKACB Antibody - 1:100 staining mouse kidney tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PRKACB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PRKACB Antibody - Immunohistochemistry of paraffin-embedded mouse lung using PRKACB antibody at dilution of 1:200 (x400 lens)
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PRKACB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
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PRKACB Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
Select
PRKACB Rabbit anti-Mouse Polyclonal (aa292-319) Antibody
Mouse, Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
Select
PRKACB Rabbit anti-Human Polyclonal (aa292-319) (Biotin) Antibody
Mouse, Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa292-319) (FITC) Antibody
Mouse, Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa292-319) (PE) Antibody
Mouse, Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa292-319) (APC) Antibody
Mouse, Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa292-319) (Azide-free) (HRP) Antibody
Mouse, Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
PRKACB Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
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PRKACB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
PRKACB Rabbit anti-Human Polyclonal (260-340 aa, C-terminal) Antibody
Mouse, Rat, Human
ELISA, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
PRKACB Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
100 µg/$331
PRKACB Antibody - Immunohistochemical analysis of PKA C beta staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with hematoxylin and mounted with DPX.
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PRKACB Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Chicken, Bovine, Rat, Pig, Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$299
Select
PRKACB Rabbit anti-Human Polyclonal (aa17-47) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
PRKACB Rabbit anti-Human Polyclonal (aa17-47) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa17-47) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa17-47) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa17-47) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
Select
PRKACB Rabbit anti-Human Polyclonal (aa17-47) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
PRKACB Antibody - Western blot analysis of extracts from Jurkat cells and COLO205 cells, using KAPCB antibody.
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PRKACB Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
PRKACB Antibody - Western blot analysis of lysates from Jurkat and COLO205 cells, using KAPCB Antibody. The lane on the right is blocked with the synthesized peptide.
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PRKACB Rabbit anti-Human Polyclonal (aa291-340) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
PRKACB Antibody - Detection limit for recombinant GST tagged PRKACB is approximately 1 ng/ml as a capture antibody.
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PRKACB Mouse anti-Human Monoclonal (2G8-1D12) Antibody
Human
ELISA
Unconjugated
100 µg/$423
Viewing 1-25 of 55 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).