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POLR3G

polymerase (RNA) III (DNA directed) polypeptide G (32kD)

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the RPC3/POLR3C-RPC6/POLR3F-RPC7/POLR3G subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during initiation. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.

Gene Name: polymerase (RNA) III (DNA directed) polypeptide G (32kD)
Synonyms: POLR3G, RPC32, RPC7, RNA polymerase III subunit C7
Target Sequences: NM_006467 NP_006458.2 O15318

Publications (1)

1
RNA polymerase III regulates cytosolic RNA:DNA hybrids and intracellular microRNA expression. Koo CX, Kobiyama K, Shen YJ, LeBert N, Ahmad S, Khatoo M, Aoshi T, Gasser S, Ishii KJ. The Journal of biological chemistry. 2015 290:7463-73. (WB; Human) [Full Text Article] [PubMed:25623070] [PMC:PMC4367256] Related Antibodies: LS-C163858.

☰ Filters
Antibodies (16)
Proteins (3)
Over-Expression Lysate (2)
Primary (16)
Recombinant (1)
POLR3G (19)
Human (16)
Mouse (3)
Rat (2)
Monkey (1)
IHC (1)
IHC-P (1)
WB (16)
ELISA (8)
IP (1)
Peptide-ELISA (2)
rabbit (16)
Product Group
IHCPlus (1)
IgG (9)
polyclonal pc (16)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (2)
FITC Conjugated (2)
HRP Conjugated (2)
PE Conjugated (1)
Unconjugated (8)
aa195-223 (7)
aa88-137 (4)
Internal (1)
No (18)
Yes (1)
GST, N-terminus (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
POLR3G Antibody - POLR3G Antibody western blot of K562 cell line lysates (35 ug/lane). The POLR3G antibody detected the POLR3G protein (arrow).
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
POLR3G Antibody - Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded (FFPE)
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POLR3G Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µl/$460
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POLR3G Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IP, WB
Unconjugated
100 µg/$351
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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POLR3G Rabbit anti-Human Polyclonal (aa195-223) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
POLR3G Antibody - Western Blot analysis of extracts from PC12 cells using POLR3G Antibody.
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POLR3G Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
POLR3G Antibody - Western blot analysis of RPC7 using HuvEc whole cells lysates
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POLR3G Rabbit anti-Human Polyclonal Antibody
Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
POLR3G Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLR3G Rabbit anti-Human Polyclonal (aa88-137) Antibody
Human
WB
Unconjugated
100 µl/$424
POLR3G Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLR3G Rabbit anti-Human Polyclonal (aa88-137) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
POLR3G Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLR3G Rabbit anti-Human Polyclonal (aa88-137) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
POLR3G Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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POLR3G Rabbit anti-Human Polyclonal (aa88-137) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
POLR3G Antibody - Western blot of POLR3G antibody at 1:500 dilution. Lane 1: MCF-7 whole cell lysate. Lane 2: Raw264.7 whole cell lysate. Lane 3: H9C2 whole cell lysate.
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POLR3G Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
50 µl/$321; 100 µl/$403
POLR3G Protein - 12.5% SDS-PAGE Stained with Coomassie Blue.
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Wheat Germ Extract
GST, N-terminus
10 µg/$479; 25 µg/$670
POLR3G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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293T Cells
Myc-DDK (Flag)
25.7 kDa
20 µg/$150
POLR3G Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
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HEK 293 Cells
Myc-DDK (Flag)
25.7 kDa
100 µg/$494
Viewing 1-19 of 19 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).