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PODXL / Podocalyxin
podocalyxin-like
Involved in the regulation of both adhesion and cell morphology and cancer progression. Function as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up inital epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.
| Gene Name: | podocalyxin-like |
| Synonyms: | PODXL, GCTM-2 antigen, gp200, PCLP, PCLP-1, PCLP1, Podocalyxin-like protein 1, Podocalyxin, Podocalyxin-like, TRA-1-60, TRA-1-81 |
| Target Sequences: | NM_005397 NP_005388.2 O00592 |
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Products
Antibodies
(88)
ELISA Kits
(28)
Proteins
(11)
Type
Competitive EIA
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Custom
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Development Kit
(1)
Over-Expression Lysate
(2)
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(88)
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(9)
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(17)
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(3)
Target
PODXL / Podocalyxin
(127)
Reactivity
Human
(80)
Mouse
(26)
Rat
(24)
Chicken
(2)
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(3)
Dog
(1)
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(3)
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(1)
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(5)
Porcine
(1)
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(10)
Application
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(35)
IHC-P
(23)
WB
(69)
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(20)
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(21)
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(1)
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(11)
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rabbit
(56)
mouse
(31)
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(1)
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(1)
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(1)
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(24)
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(17)
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(1)
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(5)
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(1)
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monoclonal mc
(31)
polyclonal pc
(57)
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(3)
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(1)
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(3)
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(1)
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(3)
5D4
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(2)
OTI2C6
(2)
OTI8D6
(2)
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PODXL/2185
(2)
SPM487
(1)
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12 x 8-Well Microstrips
(3)
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(19)
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(1)
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(1)
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(8)
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(7)
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(6)
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(3)
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(46)
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(10)
aa153-386
(8)
aa171-404
(8)
aa220-463
(8)
aa410-439
(8)
aa32-461
(6)
Internal
(4)
aa131-180
(4)
aa301-350
(4)
C-Terminus
(1)
aa100-200
(1)
aa543-557
(1)
Publications
No
(127)
Sample Type
Cell Culture Supernatants
(4)
Cell Lysates
(4)
EDTA Plasma
(1)
Heparin Plasma
(1)
Plasma
(15)
Serum
(17)
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(7)
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(3)
Tag
6His, N-terminus
(3)
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(2)
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(1)
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(1)
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(1)
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(7)
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(1)
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(2)
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293T Cells
(1)
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(4)
HEK 293 Cells
(4)
Yeast
(2)
Cancer Pathology
Cancer
PODXL / Podocalyxin Mouse anti-Human Monoclonal (53D11) Antibody
Human
Flo, IHC, IHC-P
Unconjugated
50 µg/$460
PODXL / Podocalyxin Mouse anti-Human Monoclonal (Extracellular Domain) Antibody
Human
Flo, ICC, WB
Unconjugated
100 µg/$962
PODXL / Podocalyxin Mouse anti-Human Monoclonal (FITC) (53D11) Antibody
Human
Flo
FITC Conjugated
100 µl/$430
Sandwich
96-Well Strip Plate
Rat
1.56 - 100 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Serum, Urine
1 Plate/$1,041
Yeast
6His, N-terminus
46.2 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
E. coli
6His, N-terminus
48.3 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
Yeast
6His, N-terminus
39.82 kD
100 µg/$499; 20 µg/$364; 1 mg/$1,683
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, Cell Lysates, Tissue Homogenates, Urine
1 Plate/$764
Sandwich
96-Well Strip Plate
Mouse
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$782
PODXL / Podocalyxin Mouse anti-Human Monoclonal (PE) (53D11) Antibody
Human
Flo
PE Conjugated
1 ml/$451
PODXL / Podocalyxin Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody
Mouse, Human
WB
Biotin Conjugated
0.1 ml/$416
PODXL / Podocalyxin Mouse anti-Human Monoclonal (Extracellular Domain) (3D3) Antibody
Rat, Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated
20 µg/$371; 100 µg/$574
PODXL / Podocalyxin Mouse anti-Human Monoclonal (Extracellular Domain) (Ready-to-Use) (3D3) Antibody
Rabbit, Rat, Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Ready-to-Use
7 ml/$574
PODXL / Podocalyxin Mouse anti-Human Monoclonal (Extracellular Domain) (Azide-free, BSA-free) (3D3) Antibody
Rabbit, Rat, Human
ELISA, Flo, IF, IHC, IHC-P, IP, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
PODXL / Podocalyxin Rabbit anti-Human Polyclonal (aa301-350) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
E. coli
His, N-Terminal
28.4 kDa
10 µg/$282; 50 µg/$447; 200 µg/$892; 1 mg/$2,005; 5 mg/$3,123; 2 mg/$2,192
PODXL / Podocalyxin Mouse anti-Human Monoclonal (SPM487) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$455
PODXL / Podocalyxin Goat anti-Human Polyclonal (aa543-557) Antibody
Rabbit, Mouse, Hamster, Horse, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
Sandwich
96-Well Microplate
Mouse
156 - 10000 pg/ml
Colorimetric - 450nm (TMB)
Cell Culture Supernatants, EDTA Plasma, Heparin Plasma, Serum
1 Plate/$795
PODXL / Podocalyxin Rabbit anti-Human Polyclonal (aa410-439) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Competitive EIA
96-Well Strip Plate
Mouse
0.5 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$913
Sandwich
96-Well Strip Plate
Rat
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$818
PODXL / Podocalyxin Mouse anti-Human Monoclonal (4H11) Antibody
Human
Flo, WB
Unconjugated
100 µg/$423
PODXL / Podocalyxin Mouse anti-Human Monoclonal (4D2G7) Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
50 µl/$316; 100 µl/$386
PODXL / Podocalyxin Rabbit anti-Human Polyclonal (aa220-463) Antibody
Mouse, Human
WB
Unconjugated
100 µl/$299; 200 µl/$337; 500 µl/$463; 1 ml/$527; 2 ml/$682; 5 ml/$1,141
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