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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PLN / Phospholamban Antibody (aa2‑16) LS‑C389063
Phospholamban antibody LS-C389063 is an unconjugated rabbit polyclonal antibody to Phospholamban (PLN) from human, mouse, rat and other species. Validated for WB.
Catalog
Size
Price
LS-C389063-100
100 µg (0.5 mg/ml)
$415
Description
Phospholamban antibody LS-C389063 is an unconjugated rabbit polyclonal antibody to Phospholamban (PLN) from human, mouse, rat and other species. Validated for WB.
Target
Human PLN / Phospholamban
Host
Rabbit
Reactivity
Human, Mouse, Rat, Bat, Horse, Rabbit (tested or 100% immunogen sequence identity)
Predicted
Bovine, Dog, Guinea pig, Pig, Sheep (at least 90% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Applications
  • Western blot (0.5 - 1 µg/ml)
Immunogen
Synthetic peptide from the N-terminus of human Phospholamban (EKVQYLTRSAIRRAS, aa2-16 of UniProt P26678). Percent identity by BLAST analysis: Human, Mouse, Rat, Cat, Bat, Rabbit, Horse, Opossum (100%); Sheep, Bovine, Dolphin, Elephant, Pig, Guinea pig, Dog (93%); Turkey, Chicken, Platypus, Lizard (87%); Zebra finch, Zebrafish (80%).
Epitope
aa2-16
Specificity
Human PLN / Phospholamban
Usage
Phospholamban is a 52 amino acid integral membrane protein that regulates the Ca2+ pump in cardiac muscle and skeletal muscle cells. The subsequent activation of the Ca (2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. Phospholamban is also expressed in slow-twitch skeletal muscle and some smooth muscle cells. McTiernan et al. (1999) observed that human ventricle and quadriceps displayed high levels of phospholamban transcripts and proteins, with markedly lower expression observed in smooth muscles, while the right atrium also expressed low levels of phospholamban. The structure of the human phospholamban gene closely resembles that reported for chicken, rabbit, rat, and mouse. Comparison of the human to other mammalian phospholamban genes indicated a marked conservation of sequence for at least 217 bp upstream of the transcription start site.
Presentation
Lyophilized from PBS, 2.5% BSA, 0.025% sodium azide/thimerosal.
Reconstitution
0.2 ml Sterile distilled water
Storage
Prior to reconstitution, 4°C. Following reconstitution store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PLN / Phospholamban
P26678 NM_002667 NP_002658.1

Popular PLN / Phospholamban Products

Anti-PLN / Phospholamban antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Species: Dog, Human, Bovine, Pig
Applications: IHC, IHC - Paraffin, ICC, Western blot, Immunoprecipitation
Anti-PLN / Phospholamban antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 3.75 ug/ml.
Species: Human, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Rabbit
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Antibody
Species: Human, Bovine
Applications: Western blot, ELISA
Antibody
Species: Human
Applications: IHC, Western blot, Flow Cytometry, ELISA
Antibody
Species: Human
Applications: ELISA, Dot Blot

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Images

Western blot

Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD
Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD

Western blot

Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD
Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD

Western blot

Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD
Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD

Western blot

Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD
Western blot testing of Phospholamban antibody and Lane 1: rat heart; 2: rat heart; 3: CEM; 4: MCF-7; 5: HT1080; 6: HeLa; Predicted size: 18KD; Observed size: 18KD

Requested From: United States
Date Requested: 11/21/2018
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