PIP5K1A

phosphatidylinositol-4-phosphate 5-kinase, type I, alpha

Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). PtdIns(4,5)P2 is involved in a variety of cellular processes and is the substrate to form phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3), another second messenger. The majority of PtdIns(4,5)P2 is thought to occur via type I phosphatidylinositol 4-phosphate 5-kinases given the abundance of PtdIns4P. Participates in a variety of cellular processes such as actin cytoskeleton organization, cell adhesion, migration and phagocytosis. Required for membrane ruffling formation, actin organization and focal adhesion formation during directional cell migration by controlling integrin-induced translocation of RAC1 to the plasma membrane. Together with PIP5K1C is required for phagocytosis, but they regulate different types of actin remodeling at sequential steps. Promotes particle ingestion by activating WAS that induces Arp2/3 dependent actin polymerization at the nascent phagocytic cup. Together with PIP5K1B is required after stimulation of G-protein coupled receptors for stable platelet adhesion. Plays a role during calcium-induced keratinocyte differentiation. Recruited to the plasma membrane by the E-cadherin/beta-catenin complex where it provides the substrate PtdIns(4,5)P2 for the production of PtdIns(3,4,5)P3, diacylglycerol and inositol 1,4,5-trisphosphate that mobilize internal calcium and drive keratinocyte differentiation. Together with PIP5K1C have a role during embryogenesis. Functions also in the nucleus where acts as an activator of TUT1 adenylyltransferase activity in nuclear speckles, thereby regulating mRNA polyadenylation of a select set of mRNAs.

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Products

Antibodies (22)

Proteins (9)

Type

Over-Expression Lysate (6)

Primary (22)

Recombinant (3)

Target

PIP5K1A (31)

Reactivity

Human (21)

Mouse (7)

Rat (6)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (3)

Dog (3)

Gibbon (3)

Guinea pig (3)

Hamster (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

Xenopus (3)

Zebrafish (3)

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Application

IHC (6)

IHC-P (2)

WB (22)

ELISA (9)

IF (3)

Peptide-ELISA (1)

Host

rabbit (22)

Product Group

IHCPlus (1)

Isotype

IgG (12)

Clonality

polyclonal pc (22)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (3)

FITC Conjugated (3)

HRP Conjugated (3)

PE Conjugated (1)

Unconjugated (11)

Epitope

aa19-50 (7)

Internal (5)

aa38-87 (4)

Publications

No (31)

Tag

GST (1)

GST, N-terminus (2)

Myc-DDK (Flag) (6)

Species

Human (6)

Source

293T Cells (3)

HEK 293 Cells (3)

Wheat Germ Extract (3)

Purification

Purified (1)

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IHC-plus™ PIP5K1A Antibody (Internal) LS-B10813

(4.0) Rating

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$515

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PIP5K1A Antibody LS-C755322

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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PIP5K1A Antibody LS-C676262

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$294; 100 µl/$360

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PIP5K1A Antibody LS-C409488

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PIP5K1A Antibody LS-C748426

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Rat, Human

Applications:

IF, IHC, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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PIP5K1A Antibody LS-C802947

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IHC, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

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PIP5K1A Antibody (aa19-50) LS-C330580

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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PIP5K1A Antibody (aa19-50, Biotin) LS-C220328

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PIP5K1A Antibody (aa19-50, FITC) LS-C220329

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

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PIP5K1A Antibody (aa19-50, Azide-free, HRP) LS-C220330

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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PIP5K1A Antibody (aa19-50, APC) LS-C220327

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

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PIP5K1A Antibody (aa19-50, PE) LS-C220331

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• HRP, Azide-free
• APC
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • HRP, Azide-free
  • APC
  • PE

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PIP5K1A Antibody (aa38-87) LS-C201758

Antibody:

PIP5K1A Rabbit anti-Mouse Polyclonal (aa38-87) Antibody

Reactivity:

Mouse

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

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PIP5K1A Antibody (aa38-87, HRP) LS-C468148

Antibody:

PIP5K1A Rabbit anti-Mouse Polyclonal (aa38-87) (HRP) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

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PIP5K1A Antibody (aa38-87, Biotin) LS-C468147

Antibody:

PIP5K1A Rabbit anti-Mouse Polyclonal (aa38-87) (Biotin) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PIP5K1A Antibody (aa38-87, FITC) LS-C468146

Antibody:

PIP5K1A Rabbit anti-Mouse Polyclonal (aa38-87) (FITC) Antibody

Reactivity:

Xenopus, Chicken, Zebrafish, Rat, Hamster, Pig, Horse, Bovine, Rabbit, Mouse, Dog, Guinea pig, Bat, Gibbon, Human, Monkey, Orangutan, Chimpanzee

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PIP5K1A Antibody (Internal) LS-C345578

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PIP5K1A Antibody (Internal, HRP) LS-C468145

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (Internal) (HRP) Antibody

Reactivity:

Human

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PIP5K1A Antibody (Internal, Biotin) LS-C468143

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (Internal) (Biotin) Antibody

Reactivity:

Human

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PIP5K1A Antibody (Internal, FITC) LS-C468144

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (Internal) (FITC) Antibody

Reactivity:

Human

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PIP5K1A Antibody LS-C482926

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321; 200 µl/$386

Select

PIP5K1A Antibody (aa19-50) LS-C101112

Antibody:

PIP5K1A Rabbit anti-Human Polyclonal (aa19-50) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Human PIP5K1A Protein (Recombinant GST, N-terminus) (aa258-347) - LS-G60704

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

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Human PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81826

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

61 kDa

Price:

20 µg/$215

Select

Human PIP5K1A Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G81825

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

62.5 kDa

Price:

20 µg/$150

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