PHAX

phosphorylated adaptor for RNA export

A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner By similarity. Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA.

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Products

Antibodies (26)

Proteins (3)

Type

Over-Expression Lysate (2)

Primary (26)

Recombinant (1)

Target

PHAX (29)

Reactivity

Human (26)

Mouse (5)

Rat (4)

Bovine (3)

Chimpanzee (6)

Dog (3)

Gibbon (3)

Guinea pig (3)

Horse (3)

Monkey (3)

Orangutan (3)

Pig (3)

Rabbit (3)

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Application

IHC (7)

IHC-P (1)

WB (23)

ELISA (13)

ICC (2)

IF (2)

IP (1)

Peptide-ELISA (2)

Host

rabbit (26)

Isotype

IgG (16)

Clonality

polyclonal pc (26)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (4)

FITC Conjugated (4)

HRP Conjugated (4)

PE Conjugated (1)

Unconjugated (12)

Epitope

aa297-326 (7)

aa153-202 (4)

aa306-355 (4)

110-190 aa, Internal (1)

aa141-190 (1)

aa344-394 (1)

Publications

No (29)

Tag

GST (1)

Myc-DDK (Flag) (2)

Species

Human (2)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (1)

Purification

Purified (1)

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PHAX Antibody (aa297-326) LS-C323977

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PHAX Antibody (aa297-326, Biotin) LS-C226960

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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PHAX Antibody (aa297-326, FITC) LS-C226961

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PHAX Antibody (aa297-326, APC) LS-C226959

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PHAX Antibody (aa297-326, PE) LS-C226963

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

PHAX Antibody (aa297-326, Azide-free, HRP) LS-C226962

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

PHAX Antibody (110-190 aa, Internal) LS-C385471

Antibody:

PHAX Rabbit anti-Human Polyclonal (110-190 aa, Internal) Antibody

Reactivity:

Human

Applications:

ELISA, ICC, WB

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

PHAX Antibody LS-C679007

Antibody:

PHAX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF, WB

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

Select

PHAX Antibody (HRP) LS-C679013

Antibody:

PHAX Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PHAX Antibody (Biotin) LS-C679008

Antibody:

PHAX Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PHAX Antibody (FITC) LS-C679009

Antibody:

PHAX Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PHAX Antibody LS-C805360

Antibody:

PHAX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

IF, Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µl/$379; 200 µl/$421

Select

PHAX Antibody (aa297-326) LS-C163560

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa297-326) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PHAX Antibody (aa344-394) LS-C290563

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa344-394) Antibody

Reactivity:

Mouse, Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

PHAX Antibody LS-C761006

Antibody:

PHAX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

Select

PHAX Antibody LS-C667635

Antibody:

PHAX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$341

Select

PHAX Antibody LS-C824553

Antibody:

PHAX Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PHAX Antibody (aa141-190) LS-C120347

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa141-190) Antibody

Reactivity:

Human

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

Select

PHAX Antibody (aa306-355) LS-C151989

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa306-355) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PHAX Antibody (aa306-355, HRP) LS-C473158

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa306-355) (HRP) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PHAX Antibody (aa306-355, Biotin) LS-C473156

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa306-355) (Biotin) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

Select

PHAX Antibody (aa306-355, FITC) LS-C473157

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa306-355) (FITC) Antibody

Reactivity:

Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Rat, Chimpanzee, Orangutan, Gibbon, Human, Monkey

Applications:

WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

Select

PHAX Antibody (aa153-202) LS-C186773

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa153-202) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

100 µl/$424

Select

PHAX Antibody (aa153-202, HRP) LS-C473161

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa153-202) (HRP) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

HRP Conjugated

Price:

100 µl/$469

Select

PHAX Antibody (aa153-202, Biotin) LS-C473159

Antibody:

PHAX Rabbit anti-Human Polyclonal (aa153-202) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

WB

Format:

Biotin Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin

• Unconjugated
• HRP
• Biotin

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