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PH4 / P4HTM
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
| Gene Name: | prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum) |
| Synonyms: | P4HTM, EGLN4, HIF-PH4, HIF-prolyl hydroxylase 4, p4H with transmembrane domain, PH-4, p4H-TM, HIFPH4, HPH-4, p4HTM, PH4, PHD4, Proline 4-hydroxylase |
| Target Sequences: | NM_017732 Q9NXG6 Q9NXG6 |
Publications (1)
1
Prolyl hydroxylases 2 and 3 act in gliomas as protective negative feedback regulators of hypoxia-inducible factors. Henze AT, Riedel J, Diem T, Wenner J, Flamme I, Pouyseggur J, Plate KH, Acker T. Cancer research. 2010 70:357-66.
[PubMed:20028863]
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(17)
Proteins
(4)
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Over-Expression Lysate
(2)
Primary
(17)
Recombinant
(2)
Target
PH4 / P4HTM
(21)
Reactivity
Human
(17)
Mouse
(8)
Rat
(7)
Bat
(6)
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(6)
Chimpanzee
(6)
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(6)
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(6)
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(3)
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(3)
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(6)
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(6)
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(1)
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(11)
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(4)
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(3)
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(1)
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rabbit
(17)
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(13)
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polyclonal pc
(17)
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Biotin Conjugated
(3)
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(3)
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(3)
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(8)
Epitope
aa215-264
(4)
aa323-372
(4)
aa82-563
(4)
aa450-C-term
(1)
Publications
No
(21)
Tag
GST
(1)
His-SUMO
(1)
Myc-DDK (Flag)
(2)
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Human
(3)
Source
293T Cells
(1)
E. coli
(1)
HEK 293 Cells
(1)
Wheat Germ Extract
(1)
Purification
Purified
(1)
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
E. coli
His-SUMO
70.51 kD
1 mg/$1,355; 100 µg/$420; 20 µg/$323
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PH4 / P4HTM Rabbit anti-Human Polyclonal Antibody
Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) Antibody
Human
ELISA
Unconjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) (HRP) Antibody
Human
ELISA
HRP Conjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) (Biotin) Antibody
Human
ELISA
Biotin Conjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa82-563) (FITC) Antibody
Human
ELISA
FITC Conjugated
50 µg/$294; 100 µg/$360
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) Antibody
Human
WB
Unconjugated
100 µl/$424
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) (HRP) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
HRP Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) (Biotin) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa323-372) (FITC) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Pig, Horse, Bat, Rat, Chimpanzee, Gibbon, Human, Monkey
WB
FITC Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) Antibody
Human
WB
Unconjugated
100 µl/$424
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) (HRP) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) (Biotin) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa215-264) (FITC) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Pig, Bat, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
PH4 / P4HTM Rabbit anti-Human Polyclonal (aa450-C-term) Antibody
Human
WB
Unconjugated
10 µl/$295; 100 µl/$514
293T Cells
Myc-DDK (Flag)
56.5 kDa
20 µg/$215
Wheat Germ Extract
GST
89.5 kDa
10 µg/$479; 25 µg/$670
HEK 293 Cells
Myc-DDK (Flag)
56.5 kDa
100 µg/$710
Viewing 1-21
of 21
product results
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