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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PER1 Antibody LS-C502286

PER1 antibody LS-C502286 is an unconjugated rabbit polyclonal antibody to human PER1. Validated for ELISA and IHC.
Catalog
Size
Price
LS-C502286-50
50 µg
$285
LS-C502286-100
100 µg
$385
Description
PER1 antibody LS-C502286 is an unconjugated rabbit polyclonal antibody to human PER1. Validated for ELISA and IHC.
Target
Human PER1
Host
Rabbit
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG Polyclonal
Conjugations
Unconjugated. Also available conjugated with HRP, FITC, Biotin.
Purification
Protein G purified
Modifications
Unmodified
Applications
  • IHC
  • ELISA
  • (applications tested for the base form of this product only)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
PER1 antibody was raised against recombinant Human Period circadian protein homolog 1 protein (1-294AA)
Specificity
Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and signals directly to the SCN. The central clock entrains the peripheral clocks through neuronal and hormonal signals, body temperature and feeding-related cues, aligning all clocks with the external light/dark cycle. Circadian rhythms allow an organism to achieve temporal homeostasis with its environment at the molecular level by regulating gene expression to create a peak of protein expression once every 24 hours to control when a particular physiological process is most active with respect to the solar day. Transcription and translation of core clock components (CLOCK, NPAS2, ARNTL/BMAL1, ARNTL2/BMAL2, PER1, PER2, PER3, CRY1 and CRY2) plays a critical role in rhythm generation, whereas delays imposed by post-translational modifications (PTMs) are important for determining the period (tau) of the rhythms (tau refers to the period of a rhythm and is the length, in time, of one complete cycle). A diurnal rhythm is synchronized with the day/night cycle, while the ultradian and infradian rhythms have a period shorter and longer than 24 hours, respectively. Disruptions in the circadian rhythms contribute to the pathology of cardiovascular diseases, cancer, metabolic syndromes and aging. A transcription/translation feedback loop (TTFL) forms the core of the molecular circadian clock mechanism. Transcription factors, CLOCK or NPAS2 and ARNTL/BMAL1 or ARNTL2/BMAL2, form the positive limb of the feedback loop, act in the form of a heterodimer and activate the transcription of core cloc
Presentation
PBS, pH 7.4, 0.03% Proclin 300, 50% glycerol.
Storage
Short term: -20°C; Long term: -80°C; Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PER1
O15534 NM_002616 NP_002607.2

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Immunohistochemistry

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100

Immunohistochemistry

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100
Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PER1 Antibody at dilution of 1:100

Requested From: United States
Date Requested: 4/24/2019
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