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E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation.
Gene Name: | pellino E3 ubiquitin protein ligase 1 |
Synonyms: | PELI1, Pellino 1, Pellino-1, Pellino (Drosophila) homolog 1, Pellino homolog 1 (Drosophila), PRISM, Protein pellino homolog 1, Pellino homolog 1 |
Target Sequences: | NM_020651 NP_065702.2 Q96FA3 |
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