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PDIA3 / ERp57

protein disulfide isomerase family A, member 3

PDIA3 / ERp57 encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates.

Gene Name: protein disulfide isomerase family A, member 3
Synonyms: PDIA3, 58 kDa microsomal protein, ER protein 57, ERp60, ERp61, Disulfide isomerase ER-60, Endoplasmic reticulum P58, GRP58, HsT17083, p58, Phospholipase C-alpha, PI-PLC, ER protein 60, ER60, ERp57, GRP57, Protein disulfide-isomerase A3
Target Sequences: NM_005313 NP_005304.3 P30101

Publications (2)

1
Lung epithelial protein disulfide isomerase A3 (PDIA3) plays an important role in influenza infection, inflammation, and airway mechanics. Chamberlain N, Korwin-Mihavics BR, Nakada EM, Bruno SR, Heppner DE, Chapman DG, Hoffman SM, van der Vliet A, Suratt BT, Dienz O, Alcorn JF, Anathy V. Redox biology. 2019 April;22:101129. [Full Text Article] [PubMed:30735910] [PMC:PMC6365984] Related Antibodies: LS-B9768.
2
Protein Disulfide Isomerase A3 Regulates Influenza Neuraminidase Activity and Influenza Burden in the Lung. Nicolas Chamberlain, Mona Ruban, Zoe F Mark, Sierra R Bruno, Amit Kumar, Ravishankar Chandrasekaran, Dhemerson Souza De Lima, Danielle Antos, Emily M Nakada, John F Alcorn, Vikas Anathy. International journal of molecular sciences. 2022 January;23:1078. [Full Text Article] [PubMed:35162999] [PMC:PMC8834910] Related Antibodies: LS-B9768.

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Antibodies (73)
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PDIA3 / ERp57 (103)
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PDIA3 / ERp57 Antibody - Anti-PDIA3 / ERp57 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDIA3 / ERp57 Goat anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
100 µl/$460
PDIA3 / ERp57 Antibody - Anti-PDIA3 / ERp57 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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PDIA3 / ERp57 Goat anti-Human Polyclonal (C-Terminus) Antibody
Mouse, Dog, Rat, Human, Monkey
IF, IHC, IHC-P, WB
Unconjugated
200 µg/$460
PDIA3 / ERp57 Protein
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E. coli
His
100 µg/$342; 500 µg/$641; 20 µg/$254
PDIA3 / ERp57 Antibody - Anti-PDIA3 / ERp57 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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PDIA3 / ERp57 Rabbit anti-Rat Polyclonal Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, WB
Unconjugated
50 µg/$495
PDIA3 / ERp57 ELISA Kit
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Sandwich
96-Well Strip Plate
Mouse
0.391 - 25 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PDIA3 / ERp57 Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PDIA3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PDIA3 / ERp57 Rabbit anti-Human Polyclonal (aa192-220) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PDIA3 / ERp57 ELISA Kit
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Sandwich
96-Well Microplate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$771
PDIA3 / ERp57 Antibody - Anti-PDIA3 / ERp57 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (Map.ERP57) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, IP, WB
Unconjugated
50 µg/$460
PDIA3 / ERp57 Antibody - Anti-PDIA3 / ERp57 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (Atto 488) (Map.ERP57) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, IP, WB
Atto 488 Conjugated
200 µg/$521
PDIA3 / ERp57 Antibody - Anti-PDIA3 / ERp57 antibody IHC of human uterus, endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 15 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (Atto 390) (Map.ERP57) Antibody
Rabbit, Mouse, Dog, Guinea pig, Bovine, Rat, Hamster, Pig, Human, Monkey
IHC, IHC-P, IP, WB
Atto 390 Conjugated
200 µg/$524
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PDIA3 / ERp57 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, Flo, IF, IHC, IP, WB
Unconjugated
100 µg/$331
PDIA3 / ERp57 Antibody - PDIA3 / ERp57 antibody Western blot of Fetal Kidney lysate. Antibody concentration 1 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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PDIA3 / ERp57 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
PDIA3 / ERp57 Antibody - Formalin-fixed and paraffin-embedded human lung carcinoma reacted with PDIA3 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
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PDIA3 / ERp57 Rabbit anti-Human Polyclonal (aa446-475) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
400 µl/$393
PDIA3 / ERp57 Antibody - 1:100 staining mouse testis tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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PDIA3 / ERp57 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
PDIA3 / ERp57 Antibody - IHC of paraffin-embedded Human breast tissue using anti-PDIA3 mouse monoclonal antibody.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (OTI3E1) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
PDIA3 / ERp57 Antibody - IHC of paraffin-embedded Human breast tissue using anti-PDIA3 mouse monoclonal antibody.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (Carrier-free) (OTI3E1) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PDIA3 / ERp57 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PDIA3 mouse monoclonal antibody.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (OTI3H5) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
PDIA3 / ERp57 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PDIA3 mouse monoclonal antibody.
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (aa140-505) (Carrier-free) (OTI3H5) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PDIA3 / ERp57 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PDIA3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (aa140-505) (OTI4D7) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$434
PDIA3 / ERp57 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-PDIA3 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).
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PDIA3 / ERp57 Mouse anti-Human Monoclonal (aa140-505) (Carrier-free) (OTI4D7) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
PDIA3 / ERp57 Protein - Purified recombinant protein PDIA3 was analyzed by SDS-PAGE gel and Coomassie Blue Staining
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HEK 293 Cells
Myc-DDK (Flag)
54.2 kDa
20 µg/$1,107
PDIA3 / ERp57 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
31.25 - 2000 pg/ml
Colorimetric - 450nm (TMB)
Plasma, Serum, Tissue Homogenates
1 Plate/$579
PDIA3 / ERp57 Protein - (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
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E. coli
10His, N-terminus + Myc, C-terminus
59.3 kDa
1 mg/$1,679; 100 µg/$500; 20 µg/$364
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Mammalian Cells
6His, C-terminus
Less than 1.0 EU/µg protein (determined by LAL method).
55.3 kDa
10 µg/$344; 50 µg/$584
Select
PDIA3 / ERp57 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, WB
Unconjugated
50 µg/$294; 100 µg/$360
Viewing 1-25 of 103 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).