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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PDE4B Antibody (C‑Terminus) LS‑C82359
PDE4B antibody LS-C82359 is an unconjugated rabbit polyclonal antibody to PDE4B from human, mouse and rat. Validated for IHC, IP and WB.
Catalog
Size
Price
LS-C82359-50
50 µl
$450

Popular PDE4B Products

Anti-PDE4B antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE).  This image was taken for the unconjugated form of this product. Other forms have not been tested.
Species: Human, Monkey, Rat, Bat, Bovine, Dog, Guinea pig, Horse, Pig
Applications: IHC, IHC - Paraffin, Western blot
Sample (30 ug of whole cell lysate). A: NT2D1, B: PC-3. 7.5% SDS PAGE. PDE4B antibody diluted at 1:1000.
Species: Human
Applications: Western blot
IHC of paraffin-embedded Human pancreas tissue using anti-PDE4B mouse monoclonal antibody.
Species: Human
Applications: IHC, IHC - Paraffin, Western blot, Flow Cytometry
Anti-PDE4B antibody IHC staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Species: Human, Mouse
Applications: IHC, IHC - Paraffin, Immunofluorescence, Western blot, Flow Cytometry

Product Description

PDE4B antibody LS-C82359 is an unconjugated rabbit polyclonal antibody to PDE4B from human, mouse and rat. Validated for IHC, IP and WB.

Specifications

Target
Human PDE4B
Synonyms
PDE4B, Pde-ivb, PDE32, PDE4B5, PDEIVB, Phosphodiesterase 4b, DPDE4, PDE4B3
Host
Rabbit
Reactivity
Human, Mouse, Rat (tested or 100% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Antiserum
Modifications
Unmodified
Applications
  • IHC
  • Western blot (1:2000)
  • Immunoprecipitation
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Immunogen
PDE4B antibody was raised against designed from the C-terminal region common to all 4B isoforms.
Epitope
C-Terminus
Specificity
The antibody selectively detects proteins corresponding to members of the PDE4B sub-family, in human, mouse & rat
Presentation
Antiserum diluted in PBS, 0.05% sodium azide
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PDE4B
PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. Q07343 NM_002600 NP_002591.2


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Images

Western blot

Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.
Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Western blot

Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.
Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Western blot

Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.
Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Western blot

Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.
Western blot of PDE4B antibody (1:2,000) against lysate from COS cells transfected with the indicated human PDE isoform.

Requested From: United States
Date Requested: 11/14/2018

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