PCGF2 / MEL-18

polycomb group ring finger 2

Transcriptional repressor. Binds specifically to the DNA sequence 5'-GACTNGACT-3'. Has tumor suppressor activity. May play a role in control of cell proliferation and/or neural cell development. Regulates proliferation of early T progenitor cells by maintaining expression of HES1. Also plays a role in antero-posterior specification of the axial skeleton and negative regulation of the self-renewal activity of hematopoietic stem cells. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Is not functionally redundant with BMI1; unlike BMI1 does not stimulate the E3 ubiquitin-protein ligase activity in a reconstituted PRC1-like complex.

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Products

Antibodies (15)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (15)

Recombinant (2)

Target

PCGF2 / MEL-18 (19)

Reactivity

Human (15)

Mouse (1)

Bat (1)

Bovine (1)

Dog (1)

Monkey (1)

Rabbit (1)

Application

WB (11)

ELISA (12)

IF (1)

Peptide-ELISA (1)

Host

rabbit (13)

mouse (1)

goat (1)

Isotype

IgG (11)

IgG2a,k (1)

Clonality

monoclonal mc (1)

polyclonal pc (14)

Clone

4D6 (1)

Format

APC Conjugated (1)

Azide-free (1)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (1)

Unconjugated (7)

Epitope

aa121-150 (7)

aa125-175 (1)

aa332-344 (1)

Publications

No (19)

Tag

GST (1)

GST, N-terminus (1)

Myc-DDK (Flag) (2)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (1)

Wheat Germ Extract (2)

Purification

Purified (1)

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PCGF2 / MEL-18 Antibody LS-C678949

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IF

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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PCGF2 / MEL-18 Antibody (HRP) LS-C678951

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (HRP) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

HRP Conjugated

Price:

50 µg/$294; 100 µg/$360

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PCGF2 / MEL-18 Antibody (Biotin) LS-C678950

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

Biotin Conjugated

Price:

50 µg/$294; 100 µg/$360

Select

PCGF2 / MEL-18 Antibody (FITC) LS-C678952

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (FITC) Antibody

Reactivity:

Human

Applications:

ELISA

Format:

FITC Conjugated

Price:

50 µg/$294; 100 µg/$360

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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PCGF2 / MEL-18 Antibody (clone 4D6) LS-C198481

Antibody:

PCGF2 / MEL-18 Mouse anti-Human Monoclonal (4D6) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$423

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PCGF2 / MEL-18 Antibody (aa121-150) LS-C323853

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

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PCGF2 / MEL-18 Antibody (aa121-150, Biotin) LS-C226956

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PCGF2 / MEL-18 Antibody (aa121-150, FITC) LS-C226957

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PCGF2 / MEL-18 Antibody (aa121-150, APC) LS-C226955

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PCGF2 / MEL-18 Antibody (aa121-150, PE) LS-C223597

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

PCGF2 / MEL-18 Antibody (aa121-150, Azide-free, HRP) LS-C223596

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

PCGF2 / MEL-18 Antibody LS-C781655

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

100 µg/$357

Select

PCGF2 / MEL-18 Antibody (aa332-344) LS-C34654

Antibody:

PCGF2 / MEL-18 Goat anti-Human Polyclonal (aa332-344) Antibody

Reactivity:

Rabbit, Dog, Bovine, Bat, Human, Monkey

Applications:

Peptide-ELISA, WB

Format:

Unconjugated

Price:

100 µg/$503

Select

PCGF2 / MEL-18 Antibody (aa121-150) LS-C163443

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa121-150) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PCGF2 / MEL-18 Antibody (aa125-175) LS-C290246

Antibody:

PCGF2 / MEL-18 Rabbit anti-Human Polyclonal (aa125-175) Antibody

Reactivity:

Human

Applications:

WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

Human PCGF2 / MEL-18 Protein (Recombinant GST, N-terminus) (aa236-294) - LS-G60577

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PCGF2 / MEL-18 Protein (Recombinant GST) (Full Length) - LS-G30978

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

63.58 kDa

Price:

10 µg/$479; 25 µg/$670

Select

Human PCGF2 / MEL-18 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G75592

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

20 µg/$150

Select

PCGF2 / MEL-18 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G100979

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

37.6 kDa

Price:

100 µg/$494

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