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Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting immunostaining in relation to complex human pathologies.

Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding. Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".

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PARP1 Antibody (clone 194C1439) LS‑C509
Note: This antibody replaces LS-C17221
PARP1 antibody LS-C509 is an unconjugated mouse monoclonal antibody to human PARP1. Validated for Flow and WB.
Catalog
Size
Price
LS-C509-100
100 µg (0.5 mg/ml)
$335

Popular PARP1 Products

Anti-PARP antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3432 concentration 10 ug/ml.
Species: Human, Mouse, Rat, Hamster, Xenopus, Drosophila
Applications: IHC, IHC - Paraffin, IHC - Frozen, Western blot, Immunoprecipitation, ELISA
Antibody
Species:
Applications: ICC, Western blot, Immunoprecipitation, ELISA
Anti-PARP antibody IHC of human brain, cerebellum, white matter. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B1243 concentration 10 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Anti-PARP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3395 concentration 15 ug/ml.
Species: Human, Mouse, Rat
Applications: IHC, IHC - Paraffin, Western blot
Antibody
Species: Human, Monkey, Dog, Hamster, Rabbit
Applications: ICC, Western blot, Immunoprecipitation, ELISA

Product Description

PARP1 antibody LS-C509 is an unconjugated mouse monoclonal antibody to human PARP1. Validated for Flow and WB.

Specifications

Target
Human PARP1
Synonyms
PARP1, ADPRT, ADP-ribosyltransferase NAD(+), Adp-ribosyltransferase, ADPRT1, ARTD1, ADPRT 1, Poly(ADP-ribose) synthetase, Poly(ADP-ribosyl)transferase, PARP, Poly [ADP-ribose] polymerase 1, PADPRT-1, PARP-1, Poly (ADP-ribose) polymerase 1, Poly(ADP-ribose) polymerase, Poly[ADP-ribose] synthase 1, PPOL
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG2b,k Monoclonal [194C1439]
Conjugations
Unconjugated
Purification
Protein G purified
Modifications
Unmodified
Applications
  • Western blot (1 - 2 µg/ml)
  • Flow Cytometry
Immunogen
PARP1 antibody was raised against synthetic peptide from human PARP1.
Specificity
This specifically detects a 89-kD cleavage fragment containing the catalytic and auto modification domain.
Presentation
PBS, 0.05% Sodium Azide, 0.05% BSA
Storage
Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.
Restrictions
For research use only.
About PARP1
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. P09874 NM_001618 NP_001609.2


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Images

Western blot

Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.
Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.

Western blot

Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.
Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.

Western blot

Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.
Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.

Western blot

Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.
Detection of cleaved PARP in HL-60 cell lysates. Lane A. Untreated HL-60 cells. Lane B. HL-60 cells treated with camptothecin for 12 hrs.

Requested From: United States
Date Requested: 10/19/2018

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