PAN3

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins.

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Products

Antibodies (15)

Proteins (4)

Type

Over-Expression Lysate (2)

Primary (15)

Recombinant (2)

Target

PAN3 (19)

Reactivity

Human (15)

Mouse (7)

Application

IHC (7)

IHC-P (1)

WB (15)

Flo (7)

ELISA (12)

IP (1)

Host

rabbit (15)

Isotype

IgG (13)

Clonality

polyclonal pc (15)

Format

APC Conjugated (2)

Azide-free (2)

Biotin Conjugated (2)

FITC Conjugated (2)

HRP Conjugated (2)

PE Conjugated (2)

Unconjugated (5)

Epitope

aa727-755 (7)

aa771-799 (7)

aa175-225 (1)

Publications

No (19)

Tag

GST, N-terminus (1)

Myc-DDK (Flag) (3)

Species

Human (3)

Source

293T Cells (1)

HEK 293 Cells (2)

Wheat Germ Extract (1)

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PAN3 Antibody (aa771-799) LS-C323770

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Unconjugated

Price:

200 µl/$734

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PAN3 Antibody (aa771-799, Biotin) LS-C238653

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa771-799, FITC) LS-C238654

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa771-799, APC) LS-C238655

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa771-799, PE) LS-C238659

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa771-799, Azide-free, HRP) LS-C248396

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

PAN3 Antibody (aa771-799) LS-C163353

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa771-799) Antibody

Reactivity:

Human

Applications:

Flo, IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

PAN3 Antibody (aa727-755) LS-C323771

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Unconjugated

Price:

200 µl/$734

Select

PAN3 Antibody (aa727-755, Biotin) LS-C238647

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa727-755, FITC) LS-C238648

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa727-755, APC) LS-C238646

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa727-755, PE) LS-C238651

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

PE Conjugated

Price:

200 µl/$952

Select

PAN3 Antibody (aa727-755, Azide-free, HRP) LS-C248395

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• PE
• HRP, Azide-free

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • PE
  • HRP, Azide-free

Select

PAN3 Antibody (aa175-225) LS-C762435

Antibody:

PAN3 Rabbit anti-Human Polyclonal (aa175-225) Antibody

Reactivity:

Human

Applications:

IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

PAN3 Antibody (aa727-755) LS-C164519

Antibody:

PAN3 Rabbit anti-Mouse Polyclonal (aa727-755) Antibody

Reactivity:

Mouse, Human

Applications:

WB

Format:

Unconjugated

Price:

400 µl/$393

Select

Human PAN3 Protein (Recombinant GST, N-terminus) (aa508-615) - LS-G63861

Source:

Wheat Germ Extract

Tag:

GST, N-terminus

Price:

10 µg/$479; 25 µg/$670

Select

Human PAN3 Protein (Recombinant Myc-DDK (Flag)) (Full Length) - LS-G72899

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.4 kDa

Price:

20 µg/$1,107

Select

Human PAN3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G93887

Source:

293T Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.4 kDa

Price:

20 µg/$215

Select

PAN3 Protein (Over-Expression Lysate Myc-DDK (Flag)) (Full Length) - LS-G104973

Source:

HEK 293 Cells

Tag:

Myc-DDK (Flag)

Molecular Weight:

95.4 kDa

Price:

100 µg/$710

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