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PAK1IP1 / HPIP1
PAK1 interacting protein 1
Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which have been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42.
| Gene Name: | PAK1 interacting protein 1 |
| Synonyms: | PAK1IP1, BA421M1.5, HPIP1, MAK11, PAK/PLC-interacting protein 1, PAK1-interacting protein 1, RP11-421M1.5, PIP1, PAK1 interacting protein 1, WDR84 |
| Target Sequences: | NM_017906 NP_060376.2 Q9NWT1 |
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