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OX1R / Orexin Receptor 1

hypocretin (orexin) receptor 1

Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade.

Gene Name: hypocretin (orexin) receptor 1
Family/Subfamily: GPCR , Orexin
Synonyms: HCRTR1, Hcrt receptor 1, Hypocretin receptor 1, Hypocretin type 1 receptor, Hypocretin receptor-1, Orexin receptor type 1, Orexin type 1 receptor, Orexin-1 receptor, OX1 receptor, Orexin a receptor, Orexin receptor-1, OX-R1, Orexin receptor 1, Ox1-R, OX1R, Hypocretin (orexin) receptor 1, Hypocretin receptor type 1, Ox-1-R
Target Sequences: NM_001525 NP_001516.2 O43613

Publications (2)

1
Yokukansan (Kampo medicinal formula) prevents the development of morphine tolerance by inhibiting the secretion of orexin A. Ayami Katayama, Yasuaki Kanada, Mana Tsukada, Yuko Akanuma, Haruka Takemura, Takahiro Ono, Hiroki Suga, Hitoshi Mera, Tadashi Hisamitsu, Masataka Sunagawa. Integrative medicine research. 2018 Jun;;7:141-148. [Full Text Article] [PubMed:29989049] [PMC:PMC6035380] Related Antibodies: LS-C385249.
2
Human adipose tissue is a putative direct target of daytime orexin with favorable metabolic effects: A cross-sectional study. Nir Goldstein, Hiroshi Tsuneki, Nikhil Bhandarkar, Eleonora Aimaretti, Yulia Haim, Kanta Kon, Kiyofumi Sato, Tsutomu Wada, Idit F Liberty, Boris Kirshtein, Oleg Dukhno, Nitzan Maixner, Yftach Gepner, Toshiyasu Sasaoka, Assaf Rudich. Obesity (Silver Spring, Md.). 2021 November;29:1857-1867. [Full Text Article] [PubMed:34472713] Related Antibodies: LS-C292046.

☰ Filters
Antibodies (37)
ELISA Kits (6)
Proteins (3)
Custom (3)
Primary (37)
Recombinant (3)
Sandwich (3)
OX1R / Orexin Receptor 1 (46)
Human (39)
Mouse (17)
Rat (20)
Bat (1)
Bovine (2)
Chimpanzee (6)
Dog (2)
Gibbon (3)
Hamster (1)
Horse (2)
Monkey (6)
Orangutan (6)
Pig (4)
Rabbit (2)
IHC (6)
IHC-P (4)
WB (26)
ELISA (14)
IF (4)
IP (2)
Peptide-ELISA (6)
rabbit (36)
goat (1)
Product Group
GPCR Database Antibodies (3)
IHCPlus (3)
IgG (20)
polyclonal pc (37)
96-Well Strip Plate (6)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
Magnetic beads Conjugated (1)
PE Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (24)
aa270-298 (7)
N-Terminus (5)
aa263-312 (4)
aa1-80 (3)
200-280 aa, Internal (1)
270-350 aa, Internal (1)
C-Terminus (1)
Cytoplasmic Domain (1)
Extracellular Domain (1)
aa221-270 (1)
aa231-280 (1)
aa256-291 (1)
aa298-347 (1)
aa358-370 (1)
No (44)
Yes (2)
Plasma (3)
Serum (3)
Tissue Homogenates (1)
10His, N-terminus + Myc, C-terminus (1)
6His-SUMOstar, N-terminus (1)
GST (1)
Human (3)
E. coli (1)
Wheat Germ Extract (1)
Yeast (1)
Purified (3)
OX1R / Orexin Receptor 1 Antibody - Anti-OX1R / Orexin Receptor 1 antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Dog, Pig, Horse, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$460
OX1R / Orexin Receptor 1 Antibody - Anti-HCRTR1 / Orexin Receptor 1 antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (Extracellular Domain) Antibody
Rabbit, Bovine, Rat, Pig, Human
IHC, IHC-P
Unconjugated
50 µg/$440
OX1R / Orexin Receptor 1 Antibody - Anti-HCRTR1 / Orexin Receptor 1 antibody IHC of rat brain, Purkinje neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Rat, Human, Monkey
IHC, IHC-P
Unconjugated
50 µg/$440
OX1R / Orexin Receptor 1 Antibody - Western blot analysis of the lysates from HepG2 cells using HCRTR1 antibody.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa221-270) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (270-350 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
OX1R / Orexin Receptor 1 Antibody - Western blot of lysate from human brain tissue lysate, using HCRTR1 antibody diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:10000 dilution was used as the secondary antibody. Lysate at 20 ug.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa256-291) Antibody
Human
Peptide-ELISA, WB
Unconjugated
400 µl/$393
OX1R / Orexin Receptor 1 Antibody -  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa1-80) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$380
OX1R / Orexin Receptor 1 ELISA Kit
Select
Sandwich
96-Well Strip Plate
Mouse
0.312 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
OX1R / Orexin Receptor 1 Antibody - Immunohistochemistry of paraffin-embedded Human lung cancer using HCRTR1 Polyclonal Antibody at dilution of 1:100.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
OX1R / Orexin Receptor 1 Antibody - Peptide - + Immunofluorescence analysis of MCF-7 cells, using HCRTR1 antibody.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF
Unconjugated
100 µg/$357
OX1R / Orexin Receptor 1 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using HCRTR1 Polyclonal Antibody at dilution of 1:70.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
OX1R / Orexin Receptor 1 Antibody - Immunofluorescence analysis of MCF7 cells, using HCRTR1 Antibody. The picture on the right is blocked with the synthesized peptide.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa298-347) Antibody
Mouse, Rat, Human
IF, Peptide-ELISA
Unconjugated
50 µl/$334; 100 µl/$397
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa270-298) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa270-298) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa270-298) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa270-298) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa270-298) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa270-298) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (200-280 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, WB
Unconjugated
100 µg/$331
OX1R / Orexin Receptor 1 Antibody - Western blot analysis of extracts from RAW264.7 cells, using HCRTR1 antibody.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
OX1R / Orexin Receptor 1 Antibody - Western blot of extracts from RAW264.7 cells, using HCRTR1 Antibody. The lane on the right is treated with the synthesized peptide.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal (aa231-280) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
OX1R / Orexin Receptor 1 Antibody - Western blot analysis of extracts of RAW264.7 cells using HCRTR1 antibody.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
OX1R / Orexin Receptor 1 Antibody - Immunofluorescence analysis of Rat brain using HCRTR1 Polyclonal Antibody at dilution of 1:100.Blue: DAPI for nuclear staining.
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OX1R / Orexin Receptor 1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
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OX1R / Orexin Receptor 1 Rabbit anti-Rat Polyclonal (N-Terminus) Antibody
Rat, Human
ELISA, WB
Unconjugated
50 µg/$907
Viewing 1-25 of 46 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).