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Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.
Gene Name: | OTU domain, ubiquitin aldehyde binding 2 |
Synonyms: | OTUB2, C14orf137, Deubiquitinating enzyme OTUB2, OTU2, Ubiquitin thioesterase OTUB2, OTB2, Otubain-2 |
Target Sequences: | NM_023112 NP_075601.1 Q96DC9 |
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