OAS1

2'-5'-oligoadenylate synthetase 1, 40/46kDa

Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.

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Products

Antibodies (54)

Proteins (10)

ELISA Kits (9)

Type

Custom (1)

Over-Expression Lysate (4)

Primary (54)

Recombinant (6)

Sandwich (8)

Target

OAS1 (73)

Reactivity

Human (49)

Mouse (15)

Rat (13)

Bovine (3)

Chimpanzee (12)

Dog (3)

Gibbon (3)

Horse (3)

Monkey (4)

Orangutan (6)

Pig (12)

Rabbit (3)

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Application

IHC (26)

IHC-P (19)

WB (50)

ELISA (11)

ICC (1)

IF (2)

Peptide-ELISA (2)

Host

rabbit (53)

goat (1)

Product Group

IHCPlus (4)

Isotype

IgG (25)

Clonality

polyclonal pc (54)

Format

96-Well Strip Plate (9)

APC (2)

APC Conjugated (3)

Azide-free (1)

Biotin Conjugated (9)

Cy3 Conjugated (2)

Cy7 Conjugated (2)

FITC Conjugated (9)

HRP Conjugated (9)

PE Conjugated (3)

Unconjugated (17)

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Epitope

aa139-358 (8)

aa74-165 (8)

C-Terminus (7)

aa302-330 (6)

N-Terminus (4)

aa288-337 (4)

aa324-373 (4)

Internal region (near C-Terminus) (1)

aa1-215 (1)

aa347-396 (1)

Publications

No (71)

Yes (2)

Sample Type

Plasma (8)

Serum (8)

Tissue Homogenates (3)

Tag

GST (1)

GST, N-terminus (1)

His (2)

His-T7 (1)

Myc-DDK (Flag) (5)

Species

Human (7)

Rat (1)

Source

293T Cells (2)

E. coli (3)

HEK 293 Cells (3)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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OAS1 Antibody (N-Terminus) LS-B6622

(4.0) Rating

(1) Publication(s)

Antibody:

OAS1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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OAS1 Antibody (aa324-373) LS-B6731

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa324-373) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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OAS1 Antibody (aa324-373, HRP) LS-C425945

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa324-373) (HRP) Antibody

Reactivity:

Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

HRP Conjugated

Price:

100 µl/$469

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OAS1 Antibody (aa324-373, Biotin) LS-C425943

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa324-373) (Biotin) Antibody

Reactivity:

Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

Biotin Conjugated

Price:

100 µl/$469

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OAS1 Antibody (aa324-373, FITC) LS-C425944

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa324-373) (FITC) Antibody

Reactivity:

Human, Chimpanzee

Applications:

IHC, IHC-P, WB

Format:

FITC Conjugated

Price:

100 µl/$469

• Unconjugated
• HRP
• Biotin
• FITC

• Unconjugated
• HRP
• Biotin
• More...
  • FITC

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OAS1 Antibody (aa302-330) LS-C100473

(4.2) Rating

(3) Publication(s)

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa302-330) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

400 µl/$393

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Human OAS1 (Sandwich ELISA) ELISA Kit - LS-F12205

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

1.56 - 100 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human OAS1 (Sandwich ELISA) ELISA Kit - LS-F31934

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

0.469 - 30 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$768

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Mouse OAS1 (Sandwich ELISA) ELISA Kit - LS-F14317

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

0.312 - 20 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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OAS1 Antibody LS-C749616

Antibody:

OAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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Mouse OAS1 (Sandwich ELISA) ELISA Kit - LS-F6505

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Mouse

Range:

31.2 - 2000 pmol/l

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$854

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OAS1 Antibody (aa1-215) LS-C178938

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa1-215) Antibody

Reactivity:

Human

Applications:

IHC, WB

Format:

Unconjugated

Price:

100 µl/$332

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OAS1 Antibody LS-C667654

Antibody:

OAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µl/$286; 100 µl/$321

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OAS1 Antibody (C-Terminus) LS-B6891

Antibody:

OAS1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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OAS1 Antibody (aa288-337) LS-B6632

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa288-337) Antibody

Reactivity:

Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

100 µl/$485

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Pig OAS1 (Sandwich ELISA) ELISA Kit - LS-F14316

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Pig

Range:

0.78 - 50 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$783

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Human OAS1 (Sandwich ELISA) ELISA Kit - LS-F6594

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

4.7 - 300 ng/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum

Price:

1 Plate/$834

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OAS1 Antibody LS-C667337

Antibody:

OAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, WB

Format:

Unconjugated

Price:

100 µg/$331

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OAS1 Antibody LS-C678897

Antibody:

OAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, IHC, IHC-P

Format:

Unconjugated

Price:

50 µg/$294; 100 µg/$360

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OAS1 Antibody (aa302-330, Biotin) LS-C264910

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa302-330) (Biotin) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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OAS1 Antibody (aa302-330, FITC) LS-C264911

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa302-330) (FITC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

OAS1 Antibody (aa302-330, APC) LS-C264909

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa302-330) (APC) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

OAS1 Antibody (aa302-330, Azide-free, HRP) LS-C264912

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa302-330) (Azide-free) (HRP) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

Select

OAS1 Antibody (aa302-330, PE) LS-C264915

Antibody:

OAS1 Rabbit anti-Human Polyclonal (aa302-330) (PE) Antibody

Reactivity:

Mouse, Human

Applications:

ELISA, IHC, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Biotin
• FITC
• APC
• More...
  • HRP, Azide-free
  • PE

Select

OAS1 Antibody LS-C768698

Antibody:

OAS1 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Human

Applications:

IF, WB

Format:

Unconjugated

Price:

60 µl/$331; 120 µl/$403; 200 µl/$529

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