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O3FAR1 / GPR120
free fatty acid receptor 4
Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
| Gene Name: | free fatty acid receptor 4 |
| Family/Subfamily: | GPCR , Fatty acid |
| Synonyms: | FFAR4, Free fatty acid receptor 4, GT01, GPR129, GPR120, O3FAR1, PGR4, BMIQ10 |
| Target Sequences: | NM_181745 NP_859529.2 Q5NUL3 |
Publications (6)
1
Novel identification of the free fatty acid receptor FFAR1 that promotes contraction in airway smooth muscle. Mizuta K, Zhang Y, Mizuta F, Hoshijima H, Shiga T, Masaki E, Emala CW Sr. American journal of physiology. Lung cellular and molecular physiology. 2015 309:L970-82. (WB; Human)
[Full Text Article]
[PubMed:26342087]
[PMC:PMC4628981]
2
Characterization of duodenal expression and localization of fatty acid-sensing receptors in humans: relationships with body mass index. Little TJ, Isaacs NJ, Young RL, Ott R, Nguyen NQ, Rayner CK, Horowitz M, Feinle-Bisset C. American journal of physiology. Gastrointestinal and liver physiology. 2014 307:G958-67. (IHC; Human)
[Full Text Article]
[PubMed:25258406]
Related Antibodies: LS-A2003.
3
Effects of ovarian hormones on GPR120 mRNA expression in mouse pituitary gonadotrophs. Moriyama R, Ueda K, Deura C. Endocrine Journal. 2017 November;64:1055-1061. [Full Text Article]
[PubMed:28824022]
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O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
Fast Shipping
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$460
Fast Shipping
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Human
IHC, IHC-P
Unconjugated
50 µg/$440
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa1-71) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
O3FAR1 / GPR120 Goat anti-Human Polyclonal (aa263-275) Antibody
Rabbit, Mouse, Rat, Pig, Bat, Human
IHC-P, Peptide-ELISA
Unconjugated
100 µg/$503
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa243-292) Antibody
Human
WB
Unconjugated
100 µl/$424
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa243-292) (Biotin) Antibody
Mouse, Bovine, Pig, Gibbon, Human, Chimpanzee
WB
Biotin Conjugated
100 µl/$469
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, WB
Unconjugated
50 µg/$305; 100 µg/$357
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa247-258) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
1 Each/$485
Sandwich
96-Well Strip Plate
Mouse
0.78 - 50 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$783
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (190-270 aa, Internal) Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ELISA, IF, WB
Unconjugated
100 µg/$357
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
O3FAR1 / GPR120 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
100 µg/$567
O3FAR1 / GPR120 Rabbit anti-Mouse Polyclonal (N-Terminus) Antibody
Mouse
ELISA, WB
Unconjugated
25 µl/$304
O3FAR1 / GPR120 Rabbit-New Zealand White anti-Human Polyclonal (aa250-300) Antibody
Human
IHC, WB
Unconjugated
100 µl/$393
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa28-40) Antibody
Human
ELISA, WB
Unconjugated
1 Each/$449
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (aa231-260) Antibody
Human
WB
Unconjugated
400 µl/$393
O3FAR1 / GPR120 Rabbit anti-Human Polyclonal (Internal) Antibody
Human
WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
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