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| Catalog Number | Size | Price |
|---|---|---|
| LS-A938-50 | 50 µg (0.6 mg/ml) | $440 |
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PathPlus™ Polyclonal Rabbit anti‑Human NTSR1 / NTR Antibody (Cytoplasmic Domain, IHC) LS‑A938
PathPlus™ Polyclonal Rabbit anti‑Human NTSR1 / NTR Antibody (Cytoplasmic Domain, IHC) LS‑A938
Antibody:
NTSR1 / NTR Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Overview
Antibody:
NTSR1 / NTR Rabbit anti-Human Polyclonal (Cytoplasmic Domain) Antibody
Application:
IHC, IHC-P
Reactivity:
Human
Format:
Unconjugated, Unmodified
Specifications
Description
Neurotensin receptor 1 (NTR1) activates a phosphatidylinositol-calcium second messenger system in the central and peripheral nervous systems. NTR1 mediates the functions of neurotensin, such as hypotension, hyperglycemia, hypothermia, antinociception, and regulation of intestinal motility and secretion. NTR1 expression is enhanced in pancreatic cancer and in chronic pancreatitis (Wang et al, 2000). Two differentially glycosylated forms of the NT1 receptor have been identified in rats, a 54-kD form that is expressed from birth to adulthood, and a 52-kD form only detected at 10 and 15 days postnatal.
References: The UniProt Consortium. Nucleic Acids Res. 47: D506-515 (2019); Nucleic Acids Res. 2016 Jan 4;44(D1):D733-45, PMID:26553804
Target
Human NTSR1 / NTR
Synonyms
NTSR1 | Neurotensin receptor type 1 | NT-1r | NT1 receptor | NTR | NTS1 | Neurotensin receptor 1 | NT-R-1 | NTR1 | NTRH | NTRR | Neurotensin receptor ntr1 | NTS-1 | Neurotensin type 1 receptor | NT receptor-1 | RNTR1
Host
Rabbit
Reactivity
Human
(tested or 100% immunogen sequence identity)
Predicted
Monkey (at least 90% immunogen sequence identity)
Clonality
Polyclonal
Conjugations
Unconjugated
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human NTSR1. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Monkey (94%); Marmoset, Panda, Dog, Horse (88%).
Epitope
Cytoplasmic Domain
Specificity
Human NTSR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Applications
- IHC
- IHC - Paraffin (16 µg/ml)
|
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Presentation
PBS, 0.1% Sodium Azide
Storage
Aliquot and store undiluted at -20°C or below for up to 1 year. Can be stored undiluted at 4°C for up to 1 month. Avoid freeze-thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NTSR1 / NTR
Validation
Anti-NTSR1 / NTR antibody IHC of human Bladder, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 / NTR antibody IHC of human Bladder, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Brain, Amygdala
Brain, Amygdala
Brain, globus pallidus neuron
Brain, globus pallidus neuron
Anti-NTSR1 / NTR antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 / NTR antibody IHC of human Adrenal, Pheochromocytoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 / NTR antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 / NTR antibody IHC of human Lung, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 / NTR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 / NTR antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Anti-NTSR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
See More About...
LSBio Ratings
PathPlus™ NTSR1 / NTR Antibody (Cytoplasmic Domain) for IHC LS-A938 has an LSBio Rating of
Publications (4.1)
Laboratory Validation Score (5)
Learn more about The LSBio Ratings Algorithm
Publications (2)
IFN-ß alters neurotrophic factor expression in T cells isolated from multiple sclerosis patients - implication of novel neurotensin/NTSR1 pathway in neuroprotection. Soltys J, Knight J, Scharf E, Pitt D, Mao-Draayer Y. American journal of translational research. 2014 6:312-9. (IHC; Human)
Characterisation of the Expression of Neurotensin and Its Receptors in Human Colorectal Cancer and Its Clinical Implications. Shengyang Qiu, Stella Nikolaou, Jie Zhu, Peter Jeffery, Robert Goldin, James Kinross, James L Alexander, Shahnawaz Rasheed, Paris Tekkis, Christos Kontovounisios. Biomolecules. 2020 August;10:
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Featured Products
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Species:
Human, Mouse
Applications:
IHC, IHC - Paraffin, Western blot, Peptide Enzyme-Linked Immunosorbent Assay
Species:
Human
Applications:
IHC, IHC - Paraffin
Species:
Human, Monkey
Applications:
IHC, IHC - Paraffin
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/19/2024
Date Requested: 4/19/2024
