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| Catalog Number | Size | Price |
|---|---|---|
| LS-B3526-50 | 50 µl (0.5 mg/ml) | $460 |
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Polyclonal Rabbit anti‑Human NR1H3 / LXR Alpha Antibody (C‑Terminus, IHC, WB) LS‑B3526
Polyclonal Rabbit anti‑Human NR1H3 / LXR Alpha Antibody (C‑Terminus, IHC, WB) LS‑B3526
Note: This antibody replaces LS-C80223
Toll Free North America
206-374-1102
206-374-1102For Research Use Only
Overview
Specifications
Description
LXR Alpha antibody LS-B3526 is an unconjugated rabbit polyclonal antibody to LXR Alpha (NR1H3) (C-Terminus) from human. It is reactive with human and mouse. Validated for IHC and WB. Cited in 2 publications.
Target
Human NR1H3 / LXR Alpha
Synonyms
NR1H3 | Liver X receptor alpha | LXRA | LXR-a | Oxysterols receptor LXR-alpha | LXR alpha | Lxralpha | RLD-1
Host
Rabbit
Reactivity
Human, Mouse
(tested or 100% immunogen sequence identity)
Clonality
IgG
Polyclonal
Purification
Immunoaffinity purified
Modifications
Unmodified
Immunogen
Synthetic peptide from C-Terminus of human NR1H3 (Q13133, NP_005684). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Goat, Hamster, Elephant, Panda, Dog, Bovine, Bat, Rabbit, Horse, Pig, Guinea pig, Turkey, Zebra finch, Chicken, Platypus, Lizard, Xenopus, Trout, Salmon, Stickleback, Zebrafish (100%).
Epitope
C-Terminus
Specificity
Human NR1H3 / LXR Alpha
Applications
- IHC
- IHC - Paraffin (5 µg/ml)
- Western blot
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Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents
ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
|
Usage
Immunohistochemistry: LS-B3526 was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for LS-B3526 was determined to be 5 ug/ml. ELISA titer using peptide based assay: 1:62500. Western Blot: Suggested dilution at 1 ug/ml in 5% skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1:50000 - 100000 as second antibody.
Presentation
PBS, 0.09% sodium azide, 2% sucrose
Storage
Short term: Store at 2-8°C. Long term: Aliquot and store at -20°C. Avoid freeze/thaw cycles.
Restrictions
For research use only. Intended for use by laboratory professionals.
About NR1H3 / LXR Alpha
LSBio Ratings
NR1H3 / LXR Alpha Antibody (C-Terminus) for IHC, WB/Western LS-B3526 has an LSBio Rating of
Publications (4.1)
Learn more about The LSBio Ratings Algorithm
Publications (2)
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal. Schmitt J, Kong B, Stieger B, Tschopp O, Schultze SM, Rau M, Weber A, M[Character fc]llhaupt B, Guo GL, Geier A. Liver international : official journal of the International Association for the Study of the Liver. Apr;35:1133-44.
Foam Cell Formation In Vivo Converts Macrophages to a Pro-Fibrotic Phenotype. Thomas AC, Eijgelaar WJ, Daemen MJ, Newby AC. PloS one. 2015 10:e0128163. (IHC; Mouse)
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Featured Products
Species:
Human, Rat
Applications:
IHC, Western blot, Immunoprecipitation, ELISA
Species:
Human, Rat
Applications:
Immunoprecipitation
Species:
Human, Mouse, Rat
Applications:
IHC, IHC - Paraffin, Immunofluorescence, Western blot, ELISA
Species:
Human, Mouse, Rat, Hamster
Applications:
Western blot
Reactivity:
Human
Range:
0.312-20 ng/ml
Request SDS/MSDS
To request an SDS/MSDS form for this product, please contact our Technical Support department at:
Technical.Support@LSBio.com
Requested From: United States
Date Requested: 4/24/2024
Date Requested: 4/24/2024
