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NPRA / NPR1
natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A)
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed 7982997]). The membrane guanylyl cyclases, often termed guanylyl cyclases A through F, form a family of cell-surface receptors with a similar topographic structure: an extracellular ligand-binding domain, a single membrane-spanning domain, and an intracellular region that contains a protein kinase-like domain and a cyclase catalytic domain. GC-A and GC-B function as receptors for natriuretic peptides; they are also referred to as atrial natriuretic peptide receptor A (NPR1) and type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a protein with only the ligand-binding transmembrane and 37-amino acid cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that serves as the receptor for both atrial and brain natriuretic peptides (ANP (MIM 108780) and BNP (MIM 600295), respectively).
| Gene Name: | natriuretic peptide receptor A/guanylate cyclase A (atrionatriuretic peptide receptor A) |
| Family/Subfamily: | Protein Kinase , Receptor guanylate cyclase |
| Synonyms: | NPR1, ANPR-A, ANPa, Guanylate cyclase A, GUCY2A, GC-A, GUC2A, Natriuretic peptide receptor A, NPRA, Natriuretic peptide receptor 1, NPPA receptor, ANP-A, ANPRA, NPR-A |
| Target Sequences: | NM_000906 NP_000897.3 P16066 |
Publications (2)
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