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NPR2L / TUSC4

nitrogen permease regulator-like 2 (S. cerevisiae)

Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.

Gene Name: nitrogen permease regulator-like 2 (S. cerevisiae)
Synonyms: NPRL2, G21 protein, Gene 21 protein, NPR2-like protein, NPR2L, TUSC4, Tumor suppressor candidate 4
Target Sequences: NM_006545 NP_006536.3 Q8WTW4

☰ Filters
Antibodies (23)
Proteins (3)
Over-Expression Lysate (2)
Primary (23)
Recombinant (1)
NPR2L / TUSC4 (26)
Human (23)
Mouse (13)
Rat (9)
Bat (4)
Bovine (7)
Chimpanzee (6)
Dog (4)
Gibbon (6)
Guinea pig (6)
Hamster (7)
Horse (1)
Monkey (7)
Pig (7)
Rabbit (7)
Xenopus (3)
Zebrafish (3)
IHC (8)
IHC-P (5)
WB (22)
ELISA (10)
IF (2)
IP (1)
Peptide-ELISA (2)
rabbit (22)
goat (1)
Product Group
IHCPlus (1)
IgG (17)
polyclonal pc (23)
APC Conjugated (1)
Azide-free (1)
Biotin Conjugated (3)
FITC Conjugated (3)
HRP Conjugated (3)
PE Conjugated (1)
Unconjugated (12)
aa346-373 (7)
N-Terminus (4)
aa287-336 (4)
C-terminal (1)
aa1-220 (1)
aa140-151 (1)
No (26)
GST (1)
Myc-DDK (Flag) (2)
Human (2)
293T Cells (1)
HEK 293 Cells (1)
Wheat Germ Extract (1)
Purified (1)
NPR2L / TUSC4 Antibody - Antibody (0.1 ug/ml) staining of Human Muscle lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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NPR2L / TUSC4 Goat anti-Human Polyclonal (aa140-151) Antibody
Rabbit, Mouse, Dog, Bovine, Rat, Hamster, Pig, Horse, Bat, Human, Monkey
Peptide-ELISA, WB
Unconjugated
100 µg/$503
NPR2L / TUSC4 Antibody - Immunohistochemistry of paraffin-embedded human rectum using antibody at 1:100 dilution.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa1-220) Antibody
Mouse, Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µl/$294; 100 µl/$360
NPR2L / TUSC4 Antibody - Anti-NPR2L / TUSC4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
NPR2L / TUSC4 Antibody - Anti-NPR2L / TUSC4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal (N-Terminus) (HRP) Antibody
Xenopus, Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Bat, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
HRP Conjugated
100 µl/$469
NPR2L / TUSC4 Antibody - Anti-NPR2L / TUSC4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal (N-Terminus) (Biotin) Antibody
Xenopus, Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Bat, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
Biotin Conjugated
100 µl/$469
NPR2L / TUSC4 Antibody - Anti-NPR2L / TUSC4 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal (N-Terminus) (FITC) Antibody
Xenopus, Zebrafish, Rat, Hamster, Rabbit, Mouse, Dog, Guinea pig, Bovine, Bat, Pig, Gibbon, Human, Monkey, Chimpanzee
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$341
NPR2L / TUSC4 Antibody - Immunofluorescence analysis of HeLa cells.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
IF, WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
NPR2L / TUSC4 Antibody - Immunohistochemistry of paraffin-embedded Human thyroid cancer using NPRL2 Polyclonal Antibody at dilution of 1:50.
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) Antibody
Human
ELISA, WB
Unconjugated
200 µl/$734
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) (Biotin) Antibody
Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) (FITC) Antibody
Human
ELISA, WB
FITC Conjugated
200 µl/$952
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) (APC) Antibody
Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) (Azide-free) (HRP) Antibody
Human
ELISA, WB
HRP Conjugated, Azide-free
200 µl/$952
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) (PE) Antibody
Human
ELISA, WB
PE Conjugated
200 µl/$952
NPR2L / TUSC4 Antibody - Western blot of NPRL2 antibody
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal (C-terminal) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NPR2L / TUSC4 Antibody - Western blot analysis of TUSC4 using HepG2 whole cells lysates
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NPR2L / TUSC4 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
NPR2L / TUSC4 Antibody - NPRL2 / TUSC4 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa287-336) Antibody
Human
WB
Unconjugated
100 µl/$424
NPR2L / TUSC4 Antibody - NPRL2 / TUSC4 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa287-336) (HRP) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
HRP Conjugated
100 µl/$469
NPR2L / TUSC4 Antibody - NPRL2 / TUSC4 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa287-336) (Biotin) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
Biotin Conjugated
100 µl/$469
NPR2L / TUSC4 Antibody - NPRL2 / TUSC4 antibody Western blot of NCI-H226 cell lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa287-336) (FITC) Antibody
Rabbit, Mouse, Guinea pig, Bovine, Rat, Hamster, Pig, Gibbon, Chimpanzee, Human, Monkey
WB
FITC Conjugated
100 µl/$469
NPR2L / TUSC4 Antibody - NPRL2 Antibody western blot of HL-60 cell line lysates (35 ug/lane). The NPRL2 antibody detected the NPRL2 protein (arrow).
Select
NPR2L / TUSC4 Rabbit anti-Human Polyclonal (aa346-373) Antibody
Human
WB
Unconjugated
400 µl/$393
NPR2L / TUSC4 Protein - Western validation with an anti-DDK antibody * L: Control HEK293 lysate R: Over-expression lysate
Select
293T Cells
Myc-DDK (Flag)
43.5 kDa
20 µg/$150
NPR2L / TUSC4 Protein - 12.5% SDS-PAGE of human TUSC4 stained with Coomassie Blue
Select
Wheat Germ Extract
GST
67.54 kDa
10 µg/$479; 25 µg/$670
Viewing 1-25 of 26 product results



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PLEASE NOTE

For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).