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NIX / BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. Inhibits apoptosis induced by BNIP3. Involved in mitochondrial quality control via its interaction with SPATA18/MIEAP: in response to mitochondrial damage, participates to mitochondrial protein catabolic process (also named MALM) leading to the degradation of damaged proteins inside mitochondria. The physical interaction of SPATA18/MIEAP, BNIP3 and BNIP3L/NIX at the mitochondrial outer membrane regulates the opening of a pore in the mitochondrial double membrane in order to mediate the translocation of lysosomal proteins from the cytoplasm to the mitochondrial matrix. May function as a tumor suppressor.
| Gene Name: | BCL2/adenovirus E1B 19kDa interacting protein 3-like |
| Family/Subfamily: | Apoptosis , Not assigned-Other |
| Synonyms: | BNIP3L, NIP3-like protein X, NIP3L, NIX, BNIP3a, BNIP3H |
| Target Sequences: | NM_004331 NP_004322.1 O60238 |
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