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NEUROD1

neuronal differentiation 1

Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.

Gene Name: neuronal differentiation 1
Synonyms: NEUROD1, Beta2, BHF-1, NEUROD, Neurogenic differentiation 1, MODY6, NIDDM, BHLHa3, Neuronal differentiation 1
Target Sequences: NM_002500 NP_002491.2 Q13562

Publications (2)

1
Sonic hedgehog (Shh)/Gli modulates the spatial organization of neuroepithelial cell proliferation in the developing chick optic tectum. Rapacioli M, Botelho J, Cerda G, Duarte S, Elliot M, Palma V, Flores V. BMC neuroscience. 2012 13:117. (IHC, WB; Human) [Full Text Article] [PubMed:23031710] [PMC:PMC3564940]
2
Temporal-spatial correlation between angiogenesis and corticogenesis in the developing chick optic tectum. Alejandra Rodriguez Celin, Melina Rapacioli, Mariela Azul Gonzalez, Virginia Laura Ballarin, Sara Fiszer de Plazas, Juan José López-Costa, Vladimir Flores. PloS one. 2015 January;10:e0116343. [Full Text Article] [PubMed:25633659] [PMC:PMC4310613]

☰ Filters
Antibodies (42)
Proteins (7)
Over-Expression Lysate (3)
Primary (42)
Recombinant (4)
NEUROD1 (49)
Human (42)
Mouse (24)
Rat (16)
Bat (3)
Bovine (4)
Chimpanzee (6)
Gibbon (6)
Hamster (3)
Horse (6)
Monkey (6)
Pig (3)
Xenopus (3)
IHC (13)
IHC-P (3)
WB (37)
ELISA (22)
ICC (6)
IF (10)
IP (1)
Peptide-ELISA (4)
rabbit (41)
mouse (1)
Product Group
IHCPlus (1)
IgG (33)
monoclonal mc (1)
polyclonal pc (41)
3D11 (1)
APC Conjugated (2)
Azide-free (2)
Biotin Conjugated (5)
FITC Conjugated (5)
HRP Conjugated (5)
PE Conjugated (2)
Unconjugated (23)
aa15-45 (7)
aa318-348 (7)
C-Terminus (4)
N-Terminus (4)
pSer274 (3)
210-290 aa (2)
aa240-289 (1)
p274 (1)
No (49)
6His, N-terminus (1)
GST (1)
GST, N-terminus (1)
His, N-Terminal (1)
Myc-DDK (Flag) (3)
Human (6)
293T Cells (1)
E. coli (1)
HEK 293 Cells (3)
Wheat Germ Extract (2)
Purified (2)
NEUROD1 Antibody - Immunofluorescent analysis of Hela cells diluted at 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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NEUROD1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$294; 100 µg/$360
NEUROD1 Antibody - Western blot analysis of T47D cell and pancreas cell lysate.
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NEUROD1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NEUROD1 Antibody - Anti-NEUROD1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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NEUROD1 Mouse anti-Human Monoclonal (3D11) Antibody
Human
ELISA, IHC, IHC-P, WB
Unconjugated
50 µg/$460
NEUROD1 Antibody - NeuroD1 Antibody (I333) western blot of Y79 cell line ,mouse cerebellum and rat brain tissue lysates (35 ug/lane). The NeuroD1 antibody detected the NeuroD1 protein (arrow).
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NEUROD1 Rabbit anti-Human Polyclonal (aa318-348) Antibody
Mouse, Human
WB
Unconjugated
400 µl/$393
NEUROD1 Antibody - Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
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NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NEUROD1 Antibody - A: Marker, B: Jurkat Cell Lysate.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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NEUROD1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$397
NEUROD1 Antibody - 1:100 staining mouse brain tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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NEUROD1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
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NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
200 µl/$734
Select
NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) (Biotin) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
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NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) (FITC) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
Select
NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) (APC) Antibody
Human
ELISA, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
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NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) (PE) Antibody
Human
ELISA, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
Select
NEUROD1 Rabbit anti-Human Polyclonal (aa15-45) (Azide-free) (HRP) Antibody
Human
ELISA, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
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NEUROD1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
NEUROD1 Antibody - Staining HeLa cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody, diluted at 1/600, was used as secondary antibody.
Select
NEUROD1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IF, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Select
NEUROD1 Rabbit anti-Human Polyclonal Antibody
Human
IHC, IHC-P
Unconjugated
100 µl/$412
Select
NEUROD1 Rabbit anti-Human Polyclonal (aa318-348) Antibody
Mouse, Human
ELISA, WB
Unconjugated
200 µl/$734
Select
NEUROD1 Rabbit anti-Human Polyclonal (aa318-348) (Biotin) Antibody
Mouse, Human
ELISA, WB
Biotin Conjugated
200 µl/$952
Select
NEUROD1 Rabbit anti-Human Polyclonal (aa318-348) (APC) Antibody
Mouse, Human
ELISA, WB
APC Conjugated
200 µl/$952
Select
NEUROD1 Rabbit anti-Human Polyclonal (210-290 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
Select
NEUROD1 Rabbit anti-Human Polyclonal (210-290 aa) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
NEUROD1 Antibody - Western blot analysis of extracts from HeLa cells, using Neuro D (Ab-274) antibody.
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NEUROD1 Rabbit anti-Human Polyclonal (p274) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
NEUROD1 Antibody - Western blot analysis of extracts from HeLa cells, treated with UV (15mins), using Neuro D (Phospho-Ser274) antibody.
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NEUROD1 Rabbit anti-Human Polyclonal (pSer274) Antibody
Mouse, Rat, Human
ELISA, WB
Unconjugated
100 µg/$357
NEUROD1 Antibody - Western blot analysis of lysates from HeLa cells, using Neuro D Antibody. The lane on the right is blocked with the synthesized peptide.
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NEUROD1 Rabbit anti-Human Polyclonal (aa240-289) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
NEUROD1 Antibody - Western blot analysis of lysates from HeLa cells treated with UV 15', using Neuro D (Phospho-Ser274) Antibody. The lane on the right is blocked with the phospho peptide.
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NEUROD1 Rabbit anti-Human Polyclonal (pSer274) Antibody
Mouse, Rat, Human
Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Viewing 1-25 of 49 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).