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NCL / Nucleolin

nucleolin

Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats.

Gene Name: nucleolin
Synonyms: NCL, Nucleolin, C23, Protein C23
Target Sequences: NM_005381 NP_005372.2 P19338

Publications (11)

1
Nucleolin is one component of the B cell-specific transcription factor and switch region binding protein, LR1. Hanakahi LA, Dempsey LA, Li MJ, Maizels N. Proceedings of the National Academy of Sciences of the United States of America. 1997 94:3605-10. (ICC, WB; Human) [PubMed:9108024] [PMC:PMC20487]
2
Recognition and binding of the human selenocysteine insertion sequence by nucleolin. Wu R, Shen Q, Newburger PE. Journal of cellular biochemistry. 2000 77:507-16. (WB; Human) [PubMed:10760958]
3
Up-regulation of the KLF2 transcription factor by fluid shear stress requires nucleolin. Huddleson JP, Ahmad N, Lingrel JB. The Journal of biological chemistry. 2006 281:15121-8. [PubMed:16571724]
4
Identification of novel proteins associated with both alpha-synuclein and DJ-1. Jin J, Li GJ, Davis J, Zhu D, Wang Y, Pan C, Zhang J. Molecular & cellular proteomics : MCP. 2007 6:845-59. [PubMed:16854843]
5
Selenoprotein H is a nucleolar thioredoxin-like protein with a unique expression pattern. Novoselov SV, Kryukov GV, Xu XM, Carlson BA, Hatfield DL, Gladyshev VN. The Journal of biological chemistry. 2007 282:11960-8. [PubMed:17337453]
6
Identification and characterization of nucleolin as a c-myc G-quadruplex-binding protein. Gonzlez V, Guo K, Hurley L, Sun D. The Journal of biological chemistry. 2009 284:23622-35. [PubMed:19581307] [PMC:PMC2749137]
7
Anticancer activity of CX-3543: a direct inhibitor of rRNA biogenesis. Drygin D, Siddiqui-Jain A, O'Brien S, Schwaebe M, Lin A, Bliesath J, Ho CB, Proffitt C, Trent K, Whitten JP, Lim JK, Von Hoff D, Anderes K, Rice WG. Cancer research. 2009 69:7653-61. [PubMed:19738048]
8
Role of N-end rule ubiquitin ligases UBR1 and UBR2 in regulating the leucine-mTOR signaling pathway. Kume K, Iizumi Y, Shimada M, Ito Y, Kishi T, Yamaguchi Y, Handa H. Genes to cells : devoted to molecular & cellular mechanisms. 2010 15:339-49. [PubMed:20298436]
9
Nucleolin level in plant root meristematic cells under chilling stress and recovery. Stpiski D. Micron (Oxford, England : 1993). 2012 43:870-5. (Plant) [PubMed:22483616]
10
Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor transcription in breast cancer cells. Litchfield LM, Riggs KA, Hockenberry AM, Oliver LD, Barnhart KG, Cai J, Pierce WM, Ivanova MM, Bates PJ, Appana SN, Datta S, Kulesza P, McBryan J, Young LS, Klinge CM. PloS one. 2012 7:e38278. (ICC; Human) [PubMed:22693611] [PMC:PMC3365040]
11
Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-?B-Snail signaling in glioma. Zhang B, Shi L, Lu S, Sun X, Liu Y, Li H, Wang X, Zhao C, Zhang H, Wang Y. Cancer biology & therapy. 2015 16:898-911. (IHC, WB; Human) [Full Text Article] [PubMed:25870011] [PMC:PMC4623112]
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Antibodies (82)
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NCL / Nucleolin (91)
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monoclonal mc (23)
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NCL / Nucleolin Antibody - Human Brain, Cerebellum: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (4E2) Antibody
Human
Flo, ICC, IHC, IHC-P, WB
Unconjugated
50 µg/$460
Select
Yeast
6His, N-terminus
54.4 kD
100 µg/$446; 20 µg/$336; 1 mg/$1,460
NCL / Nucleolin ELISA Kit
Select
Sandwich
96-Well Strip Plate
Human
0.156 - 10 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
NCL / Nucleolin Antibody - Detection of Human and Mouse Nucleolin by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma (left) and mouse squamous cell carcinoma (right). Antibody: Affinity purified rabbit anti-Nucleolin used at a dilution of 1:1000 (0.2 ug/ml). Detection: DAB.
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NCL / Nucleolin Rabbit anti-Human Polyclonal (aa550-C-term) Antibody
Mouse, Human
IF, IHC, IP, WB
Unconjugated
10 µl/$295; 100 µl/$514
NCL / Nucleolin Antibody - Anti-Nucleolin antibody IHC of human spleen, lymphocytes. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 1:400.
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NCL / Nucleolin Rabbit anti-Human Polyclonal (aa284-709) Antibody
Mouse, Rat, Plant, Human
IF, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
NCL / Nucleolin Antibody - IHC testing of FFPE human tonsil with Nucleolin antibody (clone NPC23-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (NPC23-2) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NCL / Nucleolin Antibody - IHC testing of FFPE human tonsil with Nucleolin antibody (clone NPC23-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
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NCL / Nucleolin Mouse anti-Human Monoclonal (Ready-to-Use) (NPC23-2) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
NCL / Nucleolin Antibody - IHC testing of FFPE human tonsil with Nucleolin antibody (clone NPC23-2).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (NPC23-2) Antibody
Mouse, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
NCL / Nucleolin Antibody - NCL Antibody (Center E443) immunohistochemistry of formalin-fixed and paraffin-embedded human breast tissue followed by peroxidase-conjugated secondary antibody and DAB staining.
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NCL / Nucleolin Rabbit anti-Human Polyclonal (aa428-455) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
NCL / Nucleolin Antibody - Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)
Select
NCL / Nucleolin Rabbit anti-Human Polyclonal (aa388-569) Antibody
Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
NCL / Nucleolin Protein - Recombinant Nucleolin By SDS-PAGE
Select
E. coli
His, N-Terminal
24.3 kDa
10 µg/$294; 50 µg/$522; 100 µg/$832; 200 µg/$1,034; 1 mg/$2,192; 500 µg/$1,712; 5 mg/$3,641; 2 mg/$2,383
NCL / Nucleolin Antibody - Immunohistochemistry of paraffin-embedded human gastric tissue.
Select
NCL / Nucleolin Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with Nucleolin antibody.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (NCL/902) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with Nucleolin antibody.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (NCL/902) Antibody
Mouse, Rat, Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with Nucleolin antibody.  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Ready-to-Use) (NCL/902) Antibody
Mouse, Rat, Human
Flo, IF, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human bladder carcinoma stained with Nucleolin antibody (364-5 + NCL/902).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (aa364-365) (364-5 + NCL/902) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human bladder carcinoma stained with Nucleolin antibody (364-5 + NCL/902).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (aa364-365) (Ready-to-Use) (364-5 + NCL/902) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human bladder carcinoma stained with Nucleolin antibody (364-5 + NCL/902).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (aa364-365) (Azide-free, BSA-free) (364-5 + NCL/902) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed paraffin-embedded human skin stained with NCL antibody (364-5).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (364-5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed paraffin-embedded human skin stained with NCL antibody (364-5).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Ready-to-Use) (364-5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Ready-to-Use
7 ml/$574
NCL / Nucleolin Antibody - Formalin-fixed paraffin-embedded human skin stained with NCL antibody (364-5).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (364-5) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with anti-Nucleolin antibody (SPM614).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (SPM614) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
20 µg/$371; 100 µg/$574
NCL / Nucleolin Antibody - Formalin-fixed, paraffin-embedded human tonsil stained with anti-Nucleolin antibody (SPM614).  This image was taken for the unmodified form of this product. Other forms have not been tested.
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Azide-free, BSA-free) (SPM614) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated, Azide-free, BSA-free
100 µg/$574
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (Biotin) (130CT43.8.5) Antibody
Human
ELISA, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
Select
NCL / Nucleolin Mouse anti-Human Monoclonal (FITC) (130CT43.8.5) Antibody
Human
ELISA, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
Viewing 1-25 of 91 product results



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The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).