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MYD88

myeloid differentiation primary response 88

The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. Recently, MyD88 was identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-kB activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.

Gene Name: myeloid differentiation primary response 88
Synonyms: MYD88, MYD88D
Target Sequences: NM_002468 NP_002459.2 Q99836

Publications (1)

1
Osteocytes directly regulate osteolysis via MYD88 signaling in bacterial bone infection. Tetsuya Yoshimoto, Mizuho Kittaka, Andrew Anh Phuong Doan, Rina Urata, Matthew Prideaux, Roxana E Rojas, Clifford V Harding, W Henry Boom, Lynda F Bonewald, Edward M Greenfield, Yasuyoshi Ueki. Nature communications. 2022 November;13:6648. [Full Text Article] [PubMed:36333322] [PMC:PMC9636212] Related Antibodies: LS-C357983.

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Antibodies (87)
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MYD88 Antibody - Anti-MYD88 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
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MYD88 Mouse anti-Human Monoclonal (1B4) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
50 µl/$440
MYD88 Antibody - Anti-MYD88 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
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MYD88 Rabbit anti-Human Polyclonal (aa233-248) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µg/$460
MYD88 Antibody - MYD88 antibody. IHC(P): Human Tonsil Tissue.
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MYD88 Rabbit anti-Human Polyclonal (aa174-188) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MYD88 Antibody - MYD88 antibody Western blot of Fetal Muscle lysate. This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MYD88 Rabbit anti-Human Polyclonal (aa71-120) Antibody
Human
WB
Unconjugated
100 µl/$424
MYD88 Antibody - IHC-P: MyD88 antibody testing of rat lung tissue
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MYD88 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
MYD88 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MYD88 mouse monoclonal antibody.
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MYD88 Mouse anti-Human Monoclonal (OTI2B2) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
MYD88 Antibody - IHC of paraffin-embedded Human Kidney tissue using anti-MYD88 mouse monoclonal antibody.
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MYD88 Mouse anti-Human Monoclonal (Carrier-free) (OTI2B2) Antibody
Human
Flo, IF, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MYD88 Antibody - Immunohistochemistry analysis of MyD88 antibody in paraffin-embedded human brain tissue.
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MYD88 Rabbit anti-Human Polyclonal (aa171-220) Antibody
Mouse, Rat, Human
IHC, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
MYD88 Protein
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E. coli
His, N-Terminal
36 kDa
10 µg/$265; 100 µg/$365; 50 µg/$315
MYD88 Antibody - Fig-1: Intracellular flow analysis of MyD88 in PBMC using 0.5 µg/10^6 cells. Green represents isotype control; red represents FITC conjugated anti-MyD88 antibody (F).
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MYD88 Mouse anti-Human Monoclonal (FITC) Antibody
Human
Flo
FITC Conjugated
25 µg/$288; 100 µg/$414
MYD88 Antibody - IHC of paraffin-embedded Carcinoma of Human bladder tissue using anti-MYD88 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min).
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MYD88 Mouse anti-Human Monoclonal (OTI1B8) Antibody
Rat, Human, Monkey
Flo, IF, IHC, IHC-P, WB
Unconjugated
100 µl/$434
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MYD88 Rabbit anti-Human Monoclonal Antibody
Mouse, Rat, Human
IP, WB
Unconjugated
100 µl/$688
MYD88 Antibody - Western blot of Jurkat whole cell lysate probed with Rabbit anti-MyD88 (RABBIT ANTI MyD88 (C-TERMINAL)).
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MYD88 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
0.1 mg/$470
MYD88 Antibody - MYD88 Antibody (4µg/ml) staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with Tris/EDTA buffer pH 9, HRP-staining. These results could not been obtained after antigen retireval at pH6 with this batch of antibody.
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MYD88 Goat anti-Human Polyclonal (Internal Region) Antibody
Human
ELISA, IHC, Peptide-ELISA, WB
Unconjugated
100 µg/$503
MYD88 Antibody - Western blot of MyD88 antibody
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MYD88 Rabbit anti-Human Polyclonal (Internal) Antibody
Mouse, Rat, Human
ELISA, ICC, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MYD88 Protein - Recombinant Myeloid Differentiation Factor 88 By SDS-PAGE
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E. coli
His
28.4 kDa
10 µg/$288; 50 µg/$482; 100 µg/$772; 200 µg/$965; 1 mg/$2,098; 500 µg/$1,627; 5 mg/$3,375; 2 mg/$2,288
MYD88 Protein
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E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
MYD88 Antibody - Fig-1: Western blot analysis of MyD88. Anti-MyD88 antibody was tested at 0.1 µg/ml on h Kidney lysate.
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MYD88 Mouse anti-Human Monoclonal Antibody
Mouse, Human
Flo, WB
Unconjugated
25 µg/$288; 100 µg/$414
MYD88 Antibody - Anti-MYD88 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2 ug/ml.
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MYD88 Rabbit anti-Human Polyclonal Antibody
Mouse, Human
ELISA, IF, IHC, IHC-P, WB
Unconjugated
0.05 mg/$460
MYD88 Antibody - Western blot of recombinant MYD88.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MYD88 Rabbit anti-Mouse Polyclonal (aa32-265) Antibody
Mouse
WB
Unconjugated
100 µl/$306; 200 µl/$347; 500 µl/$484; 1 ml/$553; 2 ml/$737; 5 ml/$1,206
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293T Cells
Myc-DDK (Flag)
33.1 kDa
20 µg/$150
MYD88 ELISA Kit
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Sandwich
96-Well Strip Plate
Rat
78.13 - 5000 pg/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$856
MYD88 Antibody - IHC of paraffin-embedded Human liver tissue using anti-MYD88 mouse monoclonal antibody.
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MYD88 Mouse anti-Human Monoclonal (OTI1A10) Antibody
Human
Flo, IHC, IHC-P, WB
Unconjugated
100 µl/$434
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MYD88 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
ICC, IF, IHC, WB
Unconjugated
50 µg/$305; 100 µg/$357
MYD88 Antibody - 1:100 staining human kidney tissue by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
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MYD88 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human, Monkey
IF, IHC, Peptide-ELISA, WB
Unconjugated
100 µl/$379; 200 µl/$421
Viewing 1-25 of 124 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).