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MtTFA / TFAM
transcription factor A, mitochondrial
Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.
| Gene Name: | transcription factor A, mitochondrial |
| Family/Subfamily: | Transcription factor , not assigned-Transcription factor |
| Synonyms: | TFAM, MTTF1, TCF-6, TCF6, TCF6L1, Transcription factor 6-like 2, Transcription factor 6-like 3, TCF6L2, TCF6L3, Transcription factor 6, Transcription factor 6-like 1, MTTFA |
| Target Sequences: | NM_003201 NP_003192.1 Q00059 |
Publications (7)
1
PGC-1 overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion. Morris EM, Meers GM, Booth FW, Fritsche KL, Hardin CD, Thyfault JP, Ibdah JA. American journal of physiology. Gastrointestinal and liver physiology. 2012 303:G979-92. (WB; Rat)
[PubMed:22899824]
[PMC:PMC3469696]
2
Pivotal Role of O-GlcNAc Modification in Cold-Induced Thermogenesis by Brown Adipose Tissue Through Mitochondrial Biogenesis. Ohashi N, Morino K, Ida S, Sekine O, Lemecha M, Kume S, Park SY, Choi CS, Ugi S, Maegawa H. Diabetes. 2017 September;66:2351-2362. [Full Text Article]
[PubMed:28637651]
Related Antibodies: LS-C30495.
3
MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-a signalling in beige adipocytes. Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, Sato D, Sekine O, Ugi S, Maegawa H. Scientific reports. 2018 October;8:15096. [Full Text Article]
[PubMed:30305668]
[PMC:PMC6180067]
Related Antibodies: LS-C30495.
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MtTFA / TFAM Mouse anti-Human Monoclonal (18G102B2E11) Antibody
Mouse, Rat, Human
ICC, IHC, IHC-P, WB
Unconjugated
0.1 ml/$460
MtTFA / TFAM Rabbit anti-Mouse Polyclonal (aa169-218) Antibody
Mouse
IHC, IHC-P, WB
Unconjugated
100 µl/$424
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa75-124) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
100 µl/$485
MtTFA / TFAM Rabbit anti-Mouse Polyclonal (aa151-200) Antibody
Mouse, Human
IHC, IHC-P, WB
Unconjugated
50 µl/$460
MtTFA / TFAM Rabbit anti-Mouse Polyclonal (aa151-200) (FITC) Antibody
Mouse, Human
IHC, IHC-P, WB
FITC Conjugated
100 µl/$469
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa131-180) Antibody
Human
IF, IHC, IHC-P, Peptide-ELISA
Unconjugated
50 µl/$460
E. coli
His
10 µg/$331; 50 µg/$567; 20 µg/$421; 100 µg/$948; 250 µg/$1,460; 500 µg/$2,301
MtTFA / TFAM Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
100 µg/$575
Sandwich
96-Well Strip Plate
Human
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Cell Lysates, Tissue Homogenates
1 Plate/$834
E. coli
His-GST
50.6 kDa
10 µg/$297; 50 µg/$542; 100 µg/$865; 200 µg/$1,065; 1 mg/$2,239; 500 µg/$1,755; 5 mg/$3,781; 2 mg/$2,430
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) Antibody
Human
Flo, IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa43-246) Antibody
Human
WB
Unconjugated
100 µl/$309; 200 µl/$351; 500 µl/$491; 1 ml/$561; 2 ml/$755; 5 ml/$1,225
Sandwich
96-Well Strip Plate
Mouse
0.313 - 20 ng/ml
Colorimetric - 450nm (TMB)
Plasma, Serum
1 Plate/$651
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa214-241) Antibody
Mouse, Rat, Human
IHC, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) Antibody
Human
ELISA, Flo, IF, IHC, WB
Unconjugated
200 µl/$734
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) (Biotin) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
Biotin Conjugated
200 µl/$952
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) (FITC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
FITC Conjugated
200 µl/$952
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) (APC) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
APC Conjugated
200 µl/$952
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) (Azide-free) (HRP) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa216-246) (PE) Antibody
Human
ELISA, Flo, ICC, IF, IHC, WB
PE Conjugated
200 µl/$952
MtTFA / TFAM Rabbit anti-Human Polyclonal (Internal) Antibody
Human
ICC, IF, IHC, IHC-P, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MtTFA / TFAM Rabbit anti-Human Polyclonal (aa227-246) Antibody
Human
ICC, IHC, IHC-Fr, IHC-P, WB
Unconjugated
10 µg/$318; 100 µg/$470
MtTFA / TFAM Rabbit anti-Human Polyclonal (100-180 aa, Internal) Antibody
Human
ELISA, IF, IHC, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MtTFA / TFAM Rabbit anti-Human Polyclonal Antibody
Human
IF, IHC, WB
Unconjugated
20 µl/$275; 100 µl/$389
MtTFA / TFAM Rabbit anti-Rat Polyclonal (aa43-244) Antibody
Rat, Human
WB
Unconjugated
100 µl/$317; 200 µl/$363; 500 µl/$515; 1 ml/$591; 2 ml/$816; 5 ml/$1,331
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