MSH2 | COCA1 | FCC1 | HNPCC | HNPCC1 | MutS protein homolog 2 | HMSH2 | LCFS2
(tested or 100% immunogen sequence identity)
Recombinant protein corresponding to the C-Terminus of human MSH2
- IHC - Paraffin (1:500)
- IHC - Frozen (1:500)
- Immunofluorescence (1:500)
- Western blot (1:500)
- Immunoprecipitation (1:500)
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Paraffin slides must be pretreated with HIER (heat induced epitope retrieval) or Proteinase K. The antibody clone FE11 is suitable to detect MSH2 in normal and carcinomatous tissue. Missing expression of MSH2 in immunohistochemistry can be used in search of MMR mutations in tumor tissues and for pre-screening. MSH2 is a protein of 934 aa (104,7 kDa) localized to the cell nucleus.It is one of the four major DNA mismatch repair (MMR) genes responsible for post- replication DNA repair. Mutations in the MSH2 gene account for the appearance of microsatellite instability found in colorectal carcinomas and other tumor entities. Germline mutations of the MSH2 gene have been linked to hereditary non-polyposis colorectal cancer (HNPCC). C-terminus of human MSH2 protein.
0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, 0.05% Sodium Azide
Store at 2°C to 8°C.
For research use only. Intended for use by laboratory professionals.
This antibody carries the LSBio 100% Guarantee.