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Catalog Number Size Price
LS-C744233-100 100 µg $870 
Antibody

Monoclonal Mouse anti‑Human MSH2 Antibody (IHC, IF, WB) LS‑C744233

Monoclonal Mouse anti‑Human MSH2 Antibody (IHC, IF, WB) LS‑C744233

Antibody:
MSH2 Mouse anti-Human Monoclonal Antibody
Application:
IHC-P, IHC-Fr, IF, WB, IP
Reactivity:
Human
Format:
Unconjugated, Unmodified
Price
Catalog Number
$870
LS-C744233-100
Toll Free North America
866-819-4732
For Research Use Only

Overview

Antibody:
MSH2 Mouse anti-Human Monoclonal Antibody
Application:
IHC-P, IHC-Fr, IF, WB, IP
Reactivity:
Human
Format:
Unconjugated, Unmodified

Specifications

Description
MSH2 antibody LS-C744233 is an unconjugated mouse monoclonal antibody to human MSH2. Validated for IF, IHC, IP and WB.
Target
Human MSH2
Synonyms
MSH2 | COCA1 | FCC1 | HNPCC | HNPCC1 | MutS protein homolog 2 | HMSH2 | LCFS2
Host
Mouse
Reactivity
Human (tested or 100% immunogen sequence identity)
Clonality
IgG1 Monoclonal
Conjugations
Unconjugated
Modifications
Unmodified
Immunogen
Recombinant protein corresponding to the C-Terminus of human MSH2
Applications
  • IHC - Paraffin (1:500)
  • IHC - Frozen (1:500)
  • Immunofluorescence (1:500)
  • Western blot (1:500)
  • Immunoprecipitation (1:500)
Performing IHC? See our complete line of Immunohistochemistry Reagents including antigen retrieval solutions, blocking agents ABC Detection Kits and polymers, biotinylated secondary antibodies, substrates and more.
Usage
Paraffin slides must be pretreated with HIER (heat induced epitope retrieval) or Proteinase K. The antibody clone FE11 is suitable to detect MSH2 in normal and carcinomatous tissue. Missing expression of MSH2 in immunohistochemistry can be used in search of MMR mutations in tumor tissues and for pre-screening. MSH2 is a protein of 934 aa (104,7 kDa) localized to the cell nucleus.It is one of the four major DNA mismatch repair (MMR) genes responsible for post- replication DNA repair. Mutations in the MSH2 gene account for the appearance of microsatellite instability found in colorectal carcinomas and other tumor entities. Germline mutations of the MSH2 gene have been linked to hereditary non-polyposis colorectal cancer (HNPCC). C-terminus of human MSH2 protein.
Presentation
0.1 M Tris-Glycine, pH 7.4, 150 mM NaCl, 0.05% Sodium Azide
Storage
Store at 2°C to 8°C.
Restrictions
For research use only. Intended for use by laboratory professionals.
Guarantee
This antibody carries the LSBio 100% Guarantee.
LSBio Guarantee
About MSH2
P43246 NM_000251 NP_000242.1

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Request SDS/MSDS

To request an SDS/MSDS form for this product, please contact our Technical Support department at:

Technical.Support@LSBio.com

Requested From: United States
Date Requested: 1/24/2022