MSH2

mutS homolog 2

Component of the post-replicative DNA mismatch repair system (MMR). Forms two different heterodimers: MutS alpha (MSH2-MSH6 heterodimer) and MutS beta (MSH2-MSH3 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. When bound, heterodimers bend the DNA helix and shields approximately 20 base pairs. MutS alpha recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. MutS beta recognizes larger insertion-deletion loops up to 13 nucleotides long. After mismatch binding, MutS alpha or beta forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch repair. MutS alpha may also play a role in DNA homologous recombination repair. In melanocytes may modulate both UV-B-induced cell cycle regulation and apoptosis.

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Products

Antibodies (53)

ELISA Kits (6)

Proteins (6)

Type

Custom (3)

Over-Expression Lysate (2)

Primary (53)

Recombinant (4)

Sandwich (2)

Sandwich CLIA (1)

Target

MSH2 (65)

Reactivity

Human (54)

Mouse (15)

Rat (17)

Bat (3)

Bovine (3)

Chicken (3)

Chimpanzee (6)

Dog (1)

Gibbon (6)

Guinea pig (3)

Hamster (6)

Horse (3)

Monkey (8)

Orangutan (6)

Pig (3)

Rabbit (3)

Xenopus (3)

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Application

IHC (20)

IHC-Fr (4)

IHC-P (10)

WB (38)

Flo (9)

ELISA (14)

ICC (9)

IF (15)

IP (7)

Peptide-ELISA (1)

Host

rabbit (38)

mouse (14)

sheep (1)

Product Group

IHCPlus (1)

Isotype

IgG (31)

IgG1 (3)

IgG1,k (1)

IgG2a (1)

IgG2a,k (1)

IgG2b (4)

Clonality

monoclonal mc (14)

polyclonal pc (36)

recombinant monoclonal rmc (3)

Clone

1184CT1.3.2 (1)

2G9 (1)

G219-1129 (1)

G410.1 (1)

RBT-MSH2 (2)

UMAB259 (2)

Format

96-Well Strip Plate (6)

APC Conjugated (1)

Azide-free (1)

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Carrier-free (1)

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HRP Conjugated (4)

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Ready-to-Use (1)

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Epitope

aa637-665 (7)

aa108-157 (4)

aa151-200 (4)

aa1-304 (2)

aa875-C-term (2)

510-590 aa, Internal (1)

C-Terminus (1)

Internal (1)

aa1-50 (1)

aa2-140 (1)

aa337-583 (1)

aa541-590 (1)

aa550-600 (1)

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Publications

No (65)

Sample Type

Plasma (3)

Serum (3)

Tissue Homogenates (1)

Tag

GST (1)

GST, N-terminus (1)

His (1)

Myc-DDK (Flag) (3)

Species

Human (5)

Source

293T Cells (1)

E. coli (1)

HEK 293 Cells (2)

Wheat Germ Extract (2)

Purification

Purified (1)

Low Endotoxin Level

Low endotoxin level (1)

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MSH2 Antibody (Internal) LS-C368893

Antibody:

MSH2 Rabbit anti-Human Polyclonal (Internal) Antibody

Reactivity:

Mouse, Dog, Rat, Human, Monkey

Applications:

ICC, IF, IHC, IHC-P, WB

Format:

Unconjugated

Price:

30 µl/$255; 100 µl/$299; 200 µl/$351

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MSH2 Antibody (clone RBT-MSH2) LS-C312105

Antibody:

MSH2 Rabbit anti-Human Recombinant Monoclonal (RBT-MSH2) Antibody

Reactivity:

Human

Applications:

IHC-Fr, IHC-P

Format:

Unconjugated

Price:

0.1 ml/$363

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IHC-plus™ MSH2 Antibody (aa550-600) LS-B1973

(4.0) Rating

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa550-600) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, WB

Format:

Unconjugated

Price:

50 µg/$460

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MSH2 Antibody LS-C331272

Antibody:

MSH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IP, WB

Format:

Unconjugated

Price:

20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503

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MSH2 Antibody LS-C666917

Antibody:

MSH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, IHC, IP, WB

Format:

Unconjugated

Price:

100 µg/$331

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MSH2 Antibody LS-C812704

Antibody:

MSH2 Mouse anti-Human Monoclonal Antibody

Reactivity:

Human, Monkey

Applications:

ELISA, IF, IHC, WB

Format:

Unconjugated

Price:

50 µg/$332; 100 µg/$404; 200 µg/$505

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MSH2 Antibody (aa337-583) LS-C357472

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa337-583) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ICC, IHC, IHC-P, WB

Format:

Unconjugated

Price:

10 µg/$318; 100 µg/$470

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MSH2 Antibody (aa637-665) LS-C323134

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, IF, WB

Format:

Unconjugated

Price:

200 µl/$734

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MSH2 Antibody (aa637-665, Biotin) LS-C226888

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) (Biotin) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

Biotin Conjugated

Price:

200 µl/$952

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MSH2 Antibody (aa637-665, FITC) LS-C226887

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) (FITC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

FITC Conjugated

Price:

200 µl/$952

Select

MSH2 Antibody (aa637-665, APC) LS-C226886

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) (APC) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

APC Conjugated

Price:

200 µl/$952

Select

MSH2 Antibody (aa637-665, Azide-free, HRP) LS-C226889

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) (Azide-free) (HRP) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

HRP Conjugated, Azide-free

Price:

200 µl/$952

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MSH2 Antibody (aa637-665, PE) LS-C226890

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) (PE) Antibody

Reactivity:

Human

Applications:

ELISA, Flo, ICC, IF, WB

Format:

PE Conjugated

Price:

200 µl/$952

• Unconjugated
• Biotin
• FITC
• APC
• HRP, Azide-free
• PE

• Unconjugated
• Biotin
• FITC
• More...
  • APC
  • HRP, Azide-free
  • PE

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MSH2 Antibody (aa541-590) LS-C119576

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa541-590) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

IF, IHC, IHC-P, Peptide-ELISA

Format:

Unconjugated

Price:

50 µl/$334; 100 µl/$397

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MSH2 Antibody (C-Terminus) LS-C9100

Antibody:

MSH2 Mouse anti-Human Monoclonal (C-Terminus) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-Fr, IHC-P, IP, WB

Format:

Unconjugated

Price:

50 µg/$807

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Human MSH2 Protein (Recombinant GST) (Full Length) - LS-G29376

Source:

Wheat Germ Extract

Tag:

GST

Molecular Weight:

131.1 kDa

Price:

10 µg/$479; 25 µg/$670

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Human MSH2 (Sandwich ELISA) ELISA Kit - LS-F35503

Type:

Sandwich

Format:

96-Well Strip Plate

Reactivity:

Human

Range:

78 - 5000 pg/ml

Detection:

Colorimetric - 450nm (TMB)

Sample Types:

Plasma, Serum, Tissue Homogenates

Price:

1 Plate/$579

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MSH2 Antibody (510-590 aa, Internal) LS-C384680

Antibody:

MSH2 Rabbit anti-Human Polyclonal (510-590 aa, Internal) Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

50 µg/$295; 100 µg/$335; 200 µg/$394

Select

MSH2 Antibody LS-C836171

Antibody:

MSH2 Rabbit Recombinant Monoclonal Antibody

Applications:

ICC, IHC, IP, WB

Format:

Unconjugated

Price:

10 µl/$299; 100 µl/$548

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MSH2 Antibody (aa875-C-term) LS-C287339

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa875-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P, IP, WB

Format:

Unconjugated

Price:

10 µl/$295; 100 µl/$514

Select

MSH2 Antibody LS-C823619

Antibody:

MSH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Mouse, Rat, Human

Applications:

ELISA, IF, IHC

Format:

Unconjugated

Price:

100 µg/$357

Select

MSH2 Antibody (aa637-665) LS-C164646

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa637-665) Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

400 µl/$393

Select

MSH2 Antibody LS-C330784

Antibody:

MSH2 Rabbit anti-Human Polyclonal Antibody

Reactivity:

Human

Applications:

Flo, IF, WB

Format:

Unconjugated

Price:

20 µl/$275; 100 µl/$389; 200 µl/$503

Select

MSH2 Antibody (clone G219-1129, Concentrated) LS-C202883

Antibody:

MSH2 Mouse anti-Human Monoclonal (Concentrated) (G219-1129) Antibody

Reactivity:

Human

Applications:

IHC, IHC-Fr, IHC-P

Format:

Unconjugated, Concentrated

Price:

1 ml/$1,196

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MSH2 Antibody (aa875-C-term) LS-C286357

Antibody:

MSH2 Rabbit anti-Human Polyclonal (aa875-C-term) Antibody

Reactivity:

Mouse, Human

Applications:

IHC, IHC-P

Format:

Unconjugated

Price:

2.5 µg/$295; 100 µl/$532

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