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MRGX1 / MRGPRX1

MAS-related GPR, member X1

Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine-induced itch, in a histamine-independent manner.

Gene Name: MAS-related GPR, member X1
Family/Subfamily: GPCR , Opioid
Synonyms: MRGPRX1, MRGX1, SNSR4, SNSR3, MAS-related GPR, member X1
Target Sequences: NM_147199 NP_671732.3 Q96LB2

Publications (1)

1
Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves. Hayley McMillan, Fionnuala T Lundy, Orla M Dunne, Banan Al-Natour , Charlotte Jeanneau, Imad About, Tim M Curtis, Ikhlas El Karim. The Breast : official journal of the European Society of Mastology. 2021 May;;35:e21492. [Full Text Article] [PubMed:33788969] Related Antibodies: LS-A2756.

☰ Filters
Antibodies (17)
Primary (17)
MRGX1 / MRGPRX1 (17)
Human (12)
Mouse (2)
Rat (6)
Monkey (1)
IHC (5)
IHC-P (4)
WB (13)
ELISA (3)
ICC (2)
IF (5)
IP (1)
Peptide-ELISA (2)
rabbit (17)
Product Group
GPCR Database Antibodies (1)
IHCPlus (1)
IgG (9)
polyclonal pc (17)
Biotin Conjugated (1)
FITC Conjugated (1)
HRP Conjugated (1)
Sepharose Conjugated (1)
Unconjugated (13)
C-Terminus (4)
N-Terminus (2)
aa14-28 (2)
240-320 aa, C-terminal (1)
aa271-320 (1)
No (16)
Yes (1)
MRGX1 / MRGPRX1 Antibody - Anti-MRGX1 / MRGPRX1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human, Monkey
ICC, IHC, IHC-P
Unconjugated
50 µg/$440
MRGX1 / MRGPRX1 Antibody - Immunofluorescent analysis of MRGX1 staining in HepG2 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a hidified chamber. Cells were washed with PBST and incubated with Alexa Fluor 647-conjugated secondary antibody (red) in PBS at room temperature in the dark.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal Antibody
Human
ICC, IF, WB
Unconjugated
30 µl/$255; 100 µl/$299; 200 µl/$351
MRGX1 / MRGPRX1 Antibody - MRGX1 / MRGPRX1 antibody Western Blot of Fetal Small Intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (C-Terminus) Antibody
Human
WB
Unconjugated
100 µl/$424
MRGX1 / MRGPRX1 Antibody - MRGX1 / MRGPRX1 antibody Western Blot of Fetal Small Intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (C-Terminus) (HRP) Antibody
Human
WB
HRP Conjugated
100 µl/$469
MRGX1 / MRGPRX1 Antibody - MRGX1 / MRGPRX1 antibody Western Blot of Fetal Small Intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (C-Terminus) (Biotin) Antibody
Human
WB
Biotin Conjugated
100 µl/$469
MRGX1 / MRGPRX1 Antibody - MRGX1 / MRGPRX1 antibody Western Blot of Fetal Small Intestine.  This image was taken for the unconjugated form of this product. Other forms have not been tested.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (C-Terminus) (FITC) Antibody
Human
WB
FITC Conjugated
100 µl/$469
Select
MRGX1 / MRGPRX1 Rabbit anti-Rat Polyclonal (aa14-28) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
100 µg/$723
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (240-320 aa, C-terminal) Antibody
Human
ELISA, IF, WB
Unconjugated
50 µg/$295; 100 µg/$335; 200 µg/$394
MRGX1 / MRGPRX1 Antibody - Immunofluorescence analysis of HepG2 cells, using MRGX1 Antibody. The picture on the right is blocked with the synthesized peptide.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal (aa271-320) Antibody
Human
IF, Peptide-ELISA, WB
Unconjugated
50 µl/$334; 100 µl/$397
Select
MRGX1 / MRGPRX1 Rabbit anti-Rat Polyclonal (aa14-28) Antibody
Rat
IHC, IHC-P, WB
Unconjugated
100 µg/$564
MRGX1 / MRGPRX1 Antibody - Staining MCF-7 cells by IF/ICC. The samples were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 min at 25°C. The primary antibody was diluted at 1:200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal Antibody
Human
IF, Peptide-ELISA
Unconjugated
100 µl/$379; 200 µl/$421
MRGX1 / MRGPRX1 Antibody
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MRGX1 / MRGPRX1 Rabbit anti-Rat Polyclonal Antibody
Rat
IHC, IHC-P, WB
Unconjugated
100 µg/$575
MRGX1 / MRGPRX1 Antibody - Peptide - + Immunofluorescence analysis of HepG2 cells, using MRGX1 antibody.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IF, WB
Unconjugated
100 µg/$357
MRGX1 / MRGPRX1 Antibody - Immunohistochemistry of paraffin-embedded Human liver cancer using MRGPRX1 Polyclonal Antibody at dilution of 1:40.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC
Unconjugated
20 µl/$254; 60 µl/$296; 120 µl/$355; 200 µl/$450
Select
MRGX1 / MRGPRX1 Rabbit anti-Mouse Polyclonal Antibody
Mouse, Rat
WB
Unconjugated
60 µl/$331; 120 µl/$403; 200 µl/$529
MRGX1 / MRGPRX1 Antibody - Western blot analysis of extracts of various cell lines, using MRGPRX1 antibody at 1:3000 dilution. The secondary antibody used was an HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates were loaded 25ug per lane and 3% nonfat dry milk in TBST was used for blocking. An ECL Kit was used for detection and the exposure time was 90s.
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MRGX1 / MRGPRX1 Rabbit anti-Human Polyclonal Antibody
Mouse, Rat, Human
WB
Unconjugated
20 µl/$275; 50 µl/$311; 100 µl/$389; 200 µl/$503
Select
MRGX1 / MRGPRX1 Rabbit anti-Rat Polyclonal (N-Terminus) (Sepharose) Antibody
Rat
IP
Sepharose Conjugated
100 µg/$399
Viewing 1-17 of 17 product results



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For RESEARCH USE ONLY. Intended for use by laboratory professionals. Not intended for human diagnostic or therapeutic purposes.

The data on this page has been compiled from LifeSpan internal sources, the National Center for Biotechnology Information (NCBI), and The Universal Protein Resource (UniProt).