Work with LifeSpan to design a custom immunohistochemistry to address your specific biological question. Outsource the entire localization process without having to
worry about finding and characterizing target specific antibodies, sourcing and validating difficult-to-find tissues, and having the ability to interpret the resulting
immunostaining in relation to complex human pathologies.
TCR Screening Services
Test your therapeutic antibodies in immunohistochemistry against a broad panel of normal frozen human tissue types in order to determine potential unintended binding.
Our non-GLP TCR services are designed on the FDA recommendation outlined in their "Points to Consider in the Manufacture and Testing of Monoclonal Antibody Products for Human Use".
(applications tested for the base form of this product only)
Specificity and Use
Human IgG4 antibody was raised against human IgG4.
Recognizes human IgG4 (kappa and lambda light chain). Fc region specific. No cross-reactivity was found against IgG1, IgG2, IgG3, IgM, IgA and IgD. Determined by hemagglutination of sheep red blood cells coated with purified human myeloma immunoglobulin, using chromic chloride. A positive reaction occurred with cells coated with IgG (Fc portion), polyclonal IgG and IgG4 (kappa or lambda light chain). Negative reaction occurred with cells coated with IgG1, IgG2, IgG3, free kappa or lambda, IgM, IgA1 (lambda), IgA2 (kappa) and IgD (lambda).
Suitable for use in ELISA.
PBS, pH 7.4, 0.09% sodium azide.
Short term 4°C, long term aliquot and store at -20°C, avoid freeze thaw cycles.