Monocytes, Macrophages

Rat

Mouse (tested or 100% immunogen sequence identity)

IgG2c Monoclonal

ER-HR3

Unconjugated

Affinity purified

Unmodified

Adherent bone marrow cells

The antigen is found on mouse monocytes and a subset of macrophages. The epitope has not been further characterized. Antigen distribution: Isolated cells: The antigen is found on up to 70% of circulating monocytes; all other leukocytes are ER-HR 3 negative. It is also found on a subpopulation (about 30%) of bone marrow cells, mainly consisting of myeloid cells. Tissue sections: In the adult mouse, the antigen is found on distinct subpopulations of resident tissue macrophages in various organs. It is found on a subpopulation of the splenic red pulp macrophages, in the mesenteric lymphoid paracortex, interfollicular areas of Peyer's patches and bone marrow. Epidermal Langerhans cells also express the antigen, whereas macrophages in the connective tissue of the dermis and the gastrointestinal tract only scarcely express the ER-HR 3 related antigen. In the kidney, ER-HR 3 positive macrophages belong to the type 2 interstitial cells in the outer medulla which are negative with BM 8. Distinct ER-HR 3 positive macrophage subpopulations are found in various embryological organs where haematopoietic islands occur, and where they are closely associated with erythrocyte precursor cells. Specificity: Mouse: subpopulation of mature macrophages. Other species: not tested

• IHC
• IHC - Paraffin (1:100)

Lyophilized from PBS pH 7.2, 10mg/ml BSA, 0.01% thimerosal

Reconstitute with 0.5ml distilled H2O.

Store at 4°C.

For research use only. Intended for use by laboratory professionals.

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