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MOB1B / MOBKL1A
MOB kinase activator 1B
Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.
| Gene Name: | MOB kinase activator 1B |
| Synonyms: | MOB1B, MOB kinase activator 1B, MOB4A, Mob1 homolog 1A, MOBKL1A, MATS2, MOB1 Mps One Binder homolog B |
| Target Sequences: | NP_775739.1 |
Publications (2)
1
Epigenetic regulation of the alternatively activated macrophage phenotype. Ishii M, Wen H, Corsa CA, Liu T, Coelho AL, Allen RM, Carson WF, Cavassani KA, Li X, Lukacs NW, Hogaboam CM, Dou Y, Kunkel SL. Blood. 2009 114:3244-54.
[PubMed:19567879]
[PMC:PMC2759649]
Related Antibodies: LS-C98948.
2
Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice. Nishio M, Hamada K, Kawahara K, Sasaki M, Noguchi F, Chiba S, Mizuno K, Suzuki SO, Dong Y, Tokuda M, Morikawa T, Hikasa H, Eggenschwiler J, Yabuta N, Nojima H, Nakagawa K, Hata Y, Nishina H, Mimori K, Mori M, Sasaki T, Mak TW, Nakano T, Itami S, Suzuki A. The Journal of clinical investigation. 2012 122:4505-18.
[PubMed:23143302]
[PMC:PMC3533542]
Related Antibodies: LS-C98948.
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(18)
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(1)
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(6)
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(2)
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(2)
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(1)
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) Antibody
Human
IF, IHC, IHC-P, WB
Unconjugated
400 µl/$393
E. coli
His
100 µg/$361; 500 µg/$739; 20 µg/$261
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa101-150) Antibody
Mouse, Human
IHC, IHC-P, Peptide-ELISA, WB
Unconjugated
50 µl/$460
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (OTI3G9) Antibody
IHC, IHC-P, WB
Unconjugated
100 µl/$434
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (Carrier-free) (OTI3G9) Antibody
Human
IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal Antibody
Human
ELISA, IHC, IP, WB
Unconjugated
100 µg/$331
Wheat Germ Extract
GST
51.5 kDa
10 µg/$479; 25 µg/$670
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) Antibody
Human
ELISA, IHC, WB
Unconjugated
200 µl/$734
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) (Biotin) Antibody
Human
ELISA, IHC, WB
Biotin Conjugated
200 µl/$952
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) (FITC) Antibody
Human
ELISA, IHC, WB
FITC Conjugated
200 µl/$952
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) (Azide-free) (HRP) Antibody
Human
ELISA, IHC, WB
HRP Conjugated, Azide-free
200 µl/$952
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) (APC) Antibody
Human
ELISA, IHC, WB
APC Conjugated
200 µl/$952
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa177-206) (PE) Antibody
Human
ELISA, IHC, WB
PE Conjugated
200 µl/$952
MOB1B / MOBKL1A Mouse anti-Human Monoclonal Antibody
Human
ICC, IF
Unconjugated
100 µl/$412
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (aa2-216) Antibody
Human
ELISA, WB
Unconjugated
50 µg/$294; 100 µg/$360
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (OTI1H2) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (Carrier-free) (OTI1H2) Antibody
Human
Flo, IHC, WB
Unconjugated, Carrier-free
100 µg/$511
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (OTI1H8) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (Carrier-free) (OTI1H8) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (OTI1F6) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (Carrier-free) (OTI1F6) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (Internal) Antibody
Zebrafish, Rat, Mouse, Bovine, Human, Monkey
IHC, IHC-P, WB
Unconjugated
100 µl/$299
MOB1B / MOBKL1A Rabbit anti-Human Polyclonal (N-Terminus) Antibody
Human
ELISA, IHC
Unconjugated
200 µl/$734
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (OTI2H4) Antibody
Human
Flo, WB
Unconjugated
100 µl/$434
MOB1B / MOBKL1A Mouse anti-Human Monoclonal (Carrier-free) (OTI2H4) Antibody
Human
Flo, WB
Unconjugated, Carrier-free
100 µg/$511
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of 57
product results
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