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MED14
mediator complex subunit 14
The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein contains a bipartite nuclear localization signal. This gene is known to escape chromosome X-inactivation.
| Gene Name: | mediator complex subunit 14 |
| Synonyms: | MED14, CSRP, CRSP2, CXorf4, CRSP150, DRIP150, EXLM1, Human homolog of yeast RGR1, HRGR1, Mediator complex subunit 14, TRAP170, RGR1 homolog, ARC150, CRSP complex subunit 2, RGR1 |
| Target Sequences: | NM_004229 NP_004220.2 O60244 |
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