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Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene.
Gene Name: | malate dehydrogenase 2, NAD (mitochondrial) |
Synonyms: | MDH2, MDH, M-MDH, MGC:3559, MOR1 |
Target Sequences: | NM_005918 NP_005909.2 P40926 |
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